| Pos. | Bench | Team | Opp. | Status |
| QB | Sam Darnold | Sea | Bye | |
| QB | Jared Goff | Det | Bye | |
| QB | Jordan Love | GB | Bye | |
| RB | Braelon Allen | NYJ | Bye | |
| RB | Michael Carter | Ari | Bye | |
| RB | Ray Davis | Buf | Bye | |
| RB | Rico Dowdle | Car | Bye | |
| RB | Isaac Guerendo | SF | Bye | Questionable |
| RB | Breece Hall | NYJ | Bye | |
| RB | Najee Harris | LAC | Bye | |
| RB | Tyjae Spears | Ten | Bye | Questionable |
| RB | Rhamondre Stevenson | NE | Bye | |
| RB | Chase Brown | Cin | Bye | Questionable |
| WR | Marquise Brown | KC | Bye | |
| WR | Zay Flowers | Bal | Bye | Questionable |
| WR | Marvin Harrison Jr. | Ari | Bye | |
| WR | Jalen McMillan | TB | Bye | |
| WR | Adonai Mitchell | Ind | Bye | |
| WR | Ricky Pearsall | SF | Bye | |
| WR | Xavier Worthy | KC | Bye | |
| WR | Jaxon Smith-Njigba | Sea | Bye | |
| WR | Jordan Addison | Min | Bye | |
| TE | Grant Calcaterra | Phi | Bye | |
| TE | Jake Ferguson | Dal | Bye | |
| TE | Dalton Kincaid | Buf | Bye | |
| TE | Isaiah Likely | Bal | Bye | |
| TE | Trey McBride | Ari | Bye | |
| DL | Nik Bonitto | Den | Bye | |
| DL | Chop Robinson | Mia | Bye | |
| DL | Jared Verse | LAR | Bye | |
| DL | Nick Bosa | SF | Bye | |
| LB | E.J. Speed | Ind | Bye | |
| S | Budda Baker | Ari | Bye |