| Pos. | Bench | Team | Opp. | Status |
| QB | Spencer Rattler | NO | Bye | |
| QB | Dorian Thompson-Robinson | Cle | Bye | |
| QB | Caleb Williams | Chi | Bye | Questionable |
| QB | Bryce Young | Car | Bye | |
| RB | Cam Akers | Min | Bye | |
| RB | Jonathon Brooks | Car | Bye | Questionable |
| RB | Austin Ekeler | Was | Bye | |
| RB | Antonio Gibson | NE | Bye | |
| RB | Kendre Miller | NO | Bye | Questionable |
| RB | Dameon Pierce | Hou | Bye | |
| RB | D'Andre Swift | Chi | Bye | |
| RB | Tyrone Tracy Jr. | NYG | Bye | |
| RB | Sean Tucker | TB | Bye | |
| RB | Emanuel Wilson | GB | Bye | |
| WR | Brandon Aiyuk | SF | Bye | Questionable |
| WR | Quentin Johnston | LAC | Bye | |
| WR | Ladd McConkey | LAC | Bye | |
| WR | Chris Olave | NO | Bye | Questionable |
| WR | Dontayvion Wicks | GB | Bye | |
| WR | Marquez Valdes-Scantling | Sea | Bye | |
| WR | Tank Dell | Hou | Bye | Questionable |
| TE | Taysom Hill | NO | Bye | Questionable |
| TE | Juwan Johnson | NO | Bye | |
| PK | Chris Boswell | Pit | Bye | |
| DL | Carl Granderson | NO | Bye | |
| DL | T.J. Watt | Pit | Bye | |
| DL | Micah Parsons | Dal | Bye | |
| DL | Greg Rousseau | Buf | Bye | |
| LB | Kaden Elliss | Atl | Bye | |
| LB | Eric Kendricks | Dal | Bye | |
| LB | Kyzir White | Ari | Bye | |
| LB | Zack Baun | Phi | Bye | |
| CB | Ja'Quan McMillian | Den | Bye |