| Pos. | Starters | Team | Opp. | Status |
| QB | Bryce Young |
|
@
|
|
| RB | James Cook |
|
@
|
|
| RB | Jahmyr Gibbs |
|
@
|
|
| WR | Rome Odunze |
|
|
Questionable |
| WR | Ladd McConkey |
|
@
|
|
| WR | Nico Collins |
|
|
|
| TE | Jake Ferguson |
|
|
Questionable |
| HB (RB) | Bucky Irving |
|
|
|
| PK | Chad Ryland |
|
@
|
|
| DL | Demarcus Lawrence |
|
|
|
| DL | Jordan Davis |
|
|
|
| DL | George Karlaftis |
|
|
|
| LB | Azeez Al-Shaair |
|
|
|
| LB | Patrick Queen |
|
|
|
| LB | Nick Bolton |
|
|
|
| CB | Cooper DeJean |
|
|
|
| S | Tykee Smith |
|
|
Out |
| Pos. | 1st Backup | Team | Opp. | Status |
| QB | Bo Nix |
|
|
|
| RB | Kyle Monangai |
|
|
|
| WR | Josh Downs |
|
@
|
|
| TE | Evan Engram |
|
|
|
| HB (TE) | Mark Andrews |
|
@
|
|
| PK | Nicholas Folk |
|
@
|
|
| LB | Bobby Okereke |
|
|
|
| CB | Isaiah Rodgers |
|
@
|
|
| Pos. | 2nd Backup | Team | Opp. | Status |
| QB | Jameis Winston |
|
|
|
| RB | Kaleb Johnson |
|
|
|
| Pos. | Bench | Team | Opp. | Status |
| QB | Kyler Murray |
|
@
|
NFI |
| RB | Braelon Allen |
|
@
|
NFI |
| WR | Xavier Legette |
|
@
|
|
| WR | JuJu Smith-Schuster |
|
|
|
| TE | Ja'Tavion Sanders |
|
@
|
|
| S | Jeremy Chinn |
|
@
|
Questionable |