| Pos. | Starters | Team | Opp. | Status |
| QB | Joe Burrow |
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|
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| RB | Kimani Vidal |
|
@
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| RB | De'Von Achane |
|
@
|
Questionable |
| WR | Xavier Worthy |
|
|
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| WR | Calvin Austin |
|
|
Questionable |
| WR | Tez Johnson |
|
|
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| TE | Tyler Warren |
|
@
|
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| HB (WR) | Chris Godwin |
|
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| PK | Tyler Loop |
|
@
|
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| DL | T.J. Watt |
|
|
Out |
| DL | Maxx Crosby |
|
@
|
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| DL | Malcolm Roach |
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|
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| LB | Edgerrin Cooper |
|
@
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|
| LB | Akeem Davis-Gaither |
|
@
|
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| LB | Ivan Pace |
|
@
|
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| CB | Joey Porter Jr. |
|
|
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| S | Ronnie Hickman |
|
@
|
|
| Pos. | 1st Backup | Team | Opp. | Status |
| QB | Jacoby Brissett |
|
@
|
|
| Pos. | Bench | Team | Opp. | Status |
| QB | C.J. Stroud |
|
|
|
| RB | Michael Carter |
|
@
|
|
| RB | Zach Charbonnet |
|
|
|
| RB | Rico Dowdle |
|
@
|
|
| RB | TreVeyon Henderson |
|
|
|
| RB | Zonovan Knight |
|
@
|
|
| RB | Devin Neal |
|
|
|
| RB | Samaje Perine |
|
|
|
| RB | Chris Rodriguez |
|
@
|
Questionable |
| RB | Tyjae Spears |
|
@
|
|
| WR | Olamide Zaccheaus |
|
|
|
| TE | Colston Loveland |
|
|
|
| DL | Joey Bosa |
|
@
|