| Pos. | Starters | Team | Opp. | Status |
| QB | Jayden Daniels |
|
@
|
Out |
| RB | Aaron Jones |
|
@
|
|
| RB | Bijan Robinson |
|
@
|
|
| WR | Cooper Kupp |
|
|
|
| WR | D.K. Metcalf |
|
|
|
| WR | Jordan Addison |
|
@
|
|
| TE | Kyle Pitts |
|
@
|
|
| HB (RB) | Kenneth Gainwell |
|
|
|
| PK | Chad Ryland |
|
@
|
|
| DL | Jared Verse |
|
|
|
| DL | Quinnen Williams |
|
|
|
| DL | Alex Highsmith |
|
|
|
| LB | Payton Wilson |
|
|
|
| LB | Patrick Queen |
|
|
|
| LB | Nick Bolton |
|
|
|
| CB | Dee Alford |
|
@
|
|
| S | Kamren Curl |
|
|
|
| Pos. | 1st Backup | Team | Opp. | Status |
| QB | Sam Darnold |
|
|
|
| RB | Tyler Allgeier |
|
@
|
|
| WR | Darnell Mooney |
|
@
|
|
| HB (WR) | Tre Tucker |
|
@
|
|
| DL | Jonathon Cooper |
|
|
|
| LB | Derrick Barnes |
|
@
|
|
| S | Talanoa Hufanga |
|
|
|
| Pos. | 2nd Backup | Team | Opp. | Status |
| QB | Marcus Mariota |
|
@
|
|
| DL | Jalen Redmond |
|
@
|
|
| S | Derwin James |
|
@
|
|
| Pos. | Bench | Team | Opp. | Status |
| RB | J.K. Dobbins |
|
|
NFI |
| RB | Kendre Miller |
|
|
NFI |
| WR | Rome Odunze |
|
|
Questionable |
| LB | Mack Wilson |
|
@
|
NFI |
| LB | Dee Winters |
|
|
|
| CB | Marcus Jones |
|
|