| Pos. | Starters | Team | Opp. | Status |
| QB | Matthew Stafford |
|
|
|
| RB | Travis Etienne |
|
|
|
| RB | Kenneth Walker |
|
|
|
| WR | Keon Coleman |
|
@
|
|
| WR | Troy Franklin |
|
|
|
| WR | DeVonta Smith |
|
|
|
| TE | Juwan Johnson |
|
|
|
| HB (WR) | Brian Thomas Jr. |
|
|
|
| PK | Jason Myers |
|
|
|
| DL | Demarcus Lawrence |
|
|
|
| DL | Anthony Nelson |
|
|
|
| DL | Jonathan Greenard |
|
@
|
|
| LB | Alex Singleton |
|
|
|
| LB | Devin White |
|
@
|
|
| LB | Pete Werner |
|
|
|
| CB | Dax Hill |
|
|
|
| S | Budda Baker |
|
@
|
|
| Pos. | 1st Backup | Team | Opp. | Status |
| QB | Baker Mayfield |
|
|
|
| WR | Jack Bech |
|
@
|
|
| HB (TE) | T.J. Hockenson |
|
@
|
|
| DL | Zach Sieler |
|
@
|
|
| Pos. | Bench | Team | Opp. | Status |
| QB | Bryce Young |
|
@
|
|
| RB | Cam Skattebo |
|
|
NFI |
| WR | Kayshon Boutte |
|
|
|
| WR | Demario Douglas |
|
|
|
| WR | Josh Palmer |
|
@
|
Questionable |
| TE | Pat Freiermuth |
|
|
|
| TE | Cade Otton |
|
|
Out |
| DL | B.J. Hill |
|
|
|
| LB | Nick Herbig |
|
|
|
| CB | Alontae Taylor |
|
|
|
| S | Quentin Lake |
|
|
NFI |