| Pos. | Bench | Team | Opp. | Status |
| QB | Trevor Lawrence | Jac | Bye | Questionable |
| QB | Patrick Mahomes | KC | Bye | |
| RB | Dalvin Cook | Dal | Bye | |
| RB | J.K. Dobbins | LAC | Bye | |
| RB | Ezekiel Elliott | Dal | Bye | |
| RB | Chuba Hubbard | Car | Bye | |
| RB | Rhamondre Stevenson | NE | Bye | |
| RB | Isiah Pacheco | KC | Bye | |
| WR | Keenan Allen | Chi | Bye | |
| WR | Nico Collins | Hou | Bye | |
| WR | Xavier Legette | Car | Bye | Questionable |
| WR | Rome Odunze | Chi | Bye | |
| WR | Alec Pierce | Ind | Bye | |
| WR | Ja'Lynn Polk | NE | Bye | Questionable |
| WR | Jordan Addison | Min | Bye | |
| WR | Josh Downs | Ind | Bye | |
| TE | Evan Engram | Den | Bye | Questionable |
| TE | Michael Mayer | LV | Bye | |
| PK | Harrison Butker | KC | Bye | |
| PK | Evan McPherson | Cin | Bye | Questionable |
| DL | Jadeveon Clowney | Car | Bye | |
| DL | Christian Wilkins | LV | Bye | Questionable |
| DL | Kwity Paye | Ind | Bye | |
| DL | Patrick Jones II | Min | Bye | |
| LB | Lavonte David | TB | Bye | |
| LB | Tremaine Edmunds | Chi | Bye | |
| LB | Jordan Hicks | Cle | Bye | Questionable |
| LB | Demario Davis | NO | Bye | |
| LB | Germaine Pratt | Cin | Bye | |
| CB | Nate Hobbs | LV | Bye | |
| CB | Tyrique Stevenson | Chi | Bye | |
| S | Minkah Fitzpatrick | Pit | Bye | |
| S | Antoine Winfield | TB | Bye |