| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| J.J. McCarthy | QB | Min | 22 | **** | ||
| Jared Goff | QB | Det | 30 | **** | ||
| Sam Darnold | QB | Sea | 27 | **** | ||
| Jordan Love | QB | GB | 26 | **** | ||
| Bryce Young | QB | Car | 23 | **** | ||
| Bijan Robinson | RB | Atl | 23 | **** | ||
| Rico Dowdle | RB | Car | 26 | **** | ||
| Breece Hall | RB | NYJ | 23 | **** | ||
| James Cook | RB | Buf | 25 | **** | ||
| Sincere McCormick | RB | LV | N/A | **** | ||
| Ray Davis | RB | Buf | 25 | **** | ||
| Braelon Allen | RB | NYJ | 21 | **** | ||
| Ladd McConkey | WR | LAC | 23 | **** | ||
| Ricky Pearsall | WR | SF | 24 | **** | ||
| Justin Jefferson | WR | Min | 26 | **** | ||
| Jameson Williams | WR | Det | 24 | **** | ||
| Cedric Tillman | WR | Cle | 25 | **** | Questionable | Concussion |
| Puka Nacua | WR | LAR | 23 | **** | ||
| Dalton Kincaid | TE | Buf | 26 | **** | ||
| Kyle Pitts | TE | Atl | 24 | **** | ||
| Isaiah Likely | TE | Bal | 25 | **** | ||
| T.J. Hockenson | TE | Min | 27 | **** | ||
| Brandon Aubrey | PK | Dal | 30 | **** | Questionable | Shoulder |
| Will Anderson | DL | Hou | 23 | **** | ||
| Nik Bonitto | DL | Den | 25 | **** | ||
| Greg Rousseau | DL | Buf | 25 | **** | ||
| Alex Highsmith | DL | Pit | 27 | **** | ||
| Andrew Van Ginkel | DL | Min | 29 | **** | ||
| DeForest Buckner | DL | Ind | 31 | **** | ||
| Tyrice Knight | LB | Sea | 24 | **** | ||
| E.J. Speed | LB | Ind | 29 | **** | ||
| Cody Barton | LB | Den | 28 | **** | ||
| Jessie Bates | S | Atl | 28 | **** |