| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | LV | 34 | **** | ||
| Brock Purdy | QB | SF | 25 | **** | ||
| Matthew Stafford | QB | LAR | 37 | **** | ||
| Sincere McCormick | RB | LV | N/A | **** | ||
| Ameer Abdullah | RB | LV | 31 | **** | ||
| Christian McCaffrey | RB | SF | 28 | **** | ||
| Joe Mixon | RB | Hou | 28 | **** | ||
| Justice Hill | RB | Bal | 27 | **** | ||
| Davante Adams | WR | LAR | 32 | **** | ||
| Ricky Pearsall | WR | SF | 24 | **** | ||
| Quentin Johnston | WR | LAC | 23 | **** | ||
| Cedric Tillman | WR | Cle | 25 | **** | Questionable | Concussion |
| Jaylen Waddle | WR | Mia | 26 | **** | ||
| Elijah Moore | WR | Cle | 25 | **** | ||
| Drake London | WR | Atl | 24 | **** | ||
| Brandon Aiyuk | WR | SF | 27 | **** | Questionable | Knee - ACL + MCL |
| Isaiah Likely | TE | Bal | 25 | **** | ||
| Dalton Kincaid | TE | Buf | 26 | **** | ||
| Brock Bowers | TE | LV | 22 | **** | ||
| Chase McLaughlin | PK | TB | 29 | **** | ||
| Chris Jones | DL | KC | 30 | **** | ||
| Myles Garrett | DL | Cle | 29 | **** | ||
| Khalil Mack | DL | LAC | 34 | **** | ||
| D.J. Wonnum | DL | Car | 27 | **** | ||
| Logan Wilson | LB | Cin | 28 | **** | Questionable | Knee |
| Zack Baun | LB | Phi | 28 | **** | ||
| Lavonte David | LB | TB | 35 | **** | ||
| Foyesade Oluokun | LB | Jac | 29 | **** | ||
| Quincy Williams | LB | NYJ | 28 | **** | ||
| Kenny Moore | CB | Ind | 29 | **** | ||
| DaRon Bland | CB | Dal | 25 | **** | ||
| Nick Cross | S | Ind | N/A | **** | ||
| Derwin James | S | LAC | 28 | **** |