| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Caleb Williams | QB | Chi | 23 | **** | Questionable | Wrist |
| Jordan Love | QB | GB | 26 | **** | ||
| Brock Purdy | QB | SF | 25 | **** | ||
| Jordan Mason | RB | Min | 25 | **** | Questionable | Ankle |
| Bijan Robinson | RB | Atl | 23 | **** | ||
| Kendre Miller | RB | NO | 22 | **** | Questionable | Concussion |
| De'Von Achane | RB | Mia | 23 | **** | ||
| Chris Rodriguez | RB | Was | 24 | **** | ||
| Blake Corum | RB | LAR | 24 | **** | Questionable | Forearm |
| Patrick Taylor | RB | SF | 27 | **** | ||
| James Cook | RB | Buf | 25 | **** | ||
| George Pickens | WR | Pit | 23 | **** | ||
| DeVonta Smith | WR | Phi | 26 | **** | ||
| Marvin Harrison Jr. | WR | Ari | 22 | **** | ||
| Xavier Legette | WR | Car | 24 | **** | Questionable | Foot |
| Demario Douglas | WR | NE | 24 | **** | ||
| Calvin Austin | WR | Pit | 26 | **** | ||
| Zay Flowers | WR | Bal | 24 | **** | Questionable | Knee |
| Jordan Addison | WR | Min | 23 | **** | ||
| Ja'Tavion Sanders | TE | Car | 22 | **** | ||
| T.J. Hockenson | TE | Min | 27 | **** | ||
| Jake Ferguson | TE | Dal | 26 | **** | ||
| Jake Moody | PK | SF | 25 | **** | ||
| Brandon Aubrey | PK | Dal | 30 | **** | Questionable | Shoulder |
| Tuli Tuipulotu | DL | LAC | 22 | **** | ||
| Zaven Collins | DL | Ari | 25 | **** | ||
| Patrick Jones II | DL | Min | 26 | **** | ||
| Grover Stewart | DL | Ind | N/A | **** | ||
| Frankie Luvu | LB | Was | 28 | **** | ||
| Kenneth Murray | LB | Ten | 26 | **** | ||
| Troy Andersen | LB | Atl | 26 | **** | Questionable | Knee |
| DaRon Bland | CB | Dal | 25 | **** | ||
| Antoine Winfield | S | TB | 26 | **** |