| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | LV | 34 | **** | ||
| Gardner Minshew | QB | LV | 28 | **** | ||
| Jared Goff | QB | Det | 30 | **** | ||
| Ty Chandler | RB | Min | 26 | **** | ||
| Antonio Gibson | RB | NE | 26 | **** | ||
| Chuba Hubbard | RB | Car | 25 | **** | ||
| Raheem Mostert | RB | LV | 33 | **** | ||
| Christian McCaffrey | RB | SF | 28 | **** | ||
| Tyler Lockett | WR | Sea | 32 | **** | ||
| Xavier Legette | WR | Car | 24 | **** | Questionable | Foot |
| Keenan Allen | WR | Chi | 33 | **** | ||
| Adam Thielen | WR | Car | 34 | **** | ||
| Garrett Wilson | WR | NYJ | 24 | **** | ||
| DeVonta Smith | WR | Phi | 26 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Cade Otton | TE | TB | 26 | **** | ||
| Travis Kelce | TE | KC | 35 | **** | ||
| Will Reichard | PK | Min | 24 | **** | ||
| Brandon Aubrey | PK | Dal | 30 | **** | Questionable | Shoulder |
| Dexter Lawrence | DL | NYG | 27 | **** | Questionable | Elbow |
| Boye Mafe | DL | Sea | 26 | **** | ||
| Jared Verse | DL | LAR | 24 | **** | ||
| Harold Landry | DL | Ten | 28 | **** | ||
| Fred Warner | LB | SF | 28 | **** | ||
| Jerome Baker | LB | Ten | 28 | **** | ||
| Demario Davis | LB | NO | 36 | **** | ||
| C.J. Mosley | LB | NYJ | 32 | **** | ||
| Eric Kendricks | LB | Dal | 33 | **** | ||
| Denzel Perryman | LB | LAC | 32 | **** | Questionable | Elbow |
| Alontae Taylor | CB | NO | N/A | **** | ||
| Tyrique Stevenson | CB | Chi | 24 | **** | ||
| Kerby Joseph | S | Det | 24 | **** | ||
| Camryn Bynum | S | Min | 26 | **** |