| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | LV | 34 | **** | ||
| Daniel Jones | QB | Ind | 27 | **** | ||
| Joe Burrow | QB | Cin | 28 | **** | ||
| Gus Edwards | RB | LAC | 30 | **** | ||
| Joe Mixon | RB | Hou | 28 | **** | ||
| Alvin Kamara | RB | NO | 29 | **** | Questionable | Groin |
| Clyde Edwards-Helaire | RB | NO | 26 | **** | ||
| Kenneth Gainwell | RB | Pit | 26 | **** | ||
| Roschon Johnson | RB | Chi | 24 | **** | ||
| David Montgomery | RB | Det | 27 | **** | ||
| Kayshon Boutte | WR | NE | N/A | **** | ||
| Rashod Bateman | WR | Bal | 25 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Amari Cooper | WR | Buf | 30 | **** | ||
| Adonai Mitchell | WR | Ind | 22 | **** | ||
| Malik Washington | WR | Mia | 24 | **** | ||
| Ja'Lynn Polk | WR | NE | 23 | **** | Questionable | Shoulder |
| D.J. Moore | WR | Chi | 28 | **** | ||
| Justin Jefferson | WR | Min | 26 | **** | ||
| Hunter Henry | TE | NE | 30 | **** | Questionable | Foot |
| Jake Ferguson | TE | Dal | 26 | **** | ||
| Travon Walker | DL | Jac | 24 | **** | ||
| Nik Bonitto | DL | Den | 25 | **** | ||
| Rashan Gary | DL | GB | 27 | **** | ||
| T.J. Watt | DL | Pit | 30 | **** | ||
| Anthony Walker | LB | Mia | 29 | **** | ||
| Jordan Hicks | LB | Cle | 32 | **** | Questionable | Concussion |
| Kenneth Murray | LB | Ten | 26 | **** | ||
| Kyzir White | LB | Ari | 29 | **** | ||
| Nakobe Dean | LB | Phi | 24 | **** | Questionable | Knee |
| Isaiah McDuffie | LB | GB | 25 | **** | ||
| Taron Johnson | CB | Buf | 28 | **** | ||
| Brian Branch | S | Det | 23 | **** |