| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Bo Nix | QB | Den | 25 | **** | ||
| Sam Darnold | QB | Sea | 27 | **** | ||
| Jalen Hurts | QB | Phi | 26 | **** | ||
| Jonathan Taylor | RB | Ind | 26 | **** | ||
| Josh Jacobs | RB | GB | 27 | **** | ||
| Travis Etienne | RB | Jac | 26 | **** | ||
| Keaton Mitchell | RB | Bal | 23 | **** | ||
| Puka Nacua | WR | LAR | 23 | **** | ||
| Demario Douglas | WR | NE | 24 | **** | ||
| Jameson Williams | WR | Det | 24 | **** | ||
| Calvin Austin | WR | Pit | 26 | **** | ||
| Tee Higgins | WR | Cin | 26 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Mark Andrews | TE | Bal | 28 | **** | ||
| Isaiah Likely | TE | Bal | 25 | **** | ||
| Brandon Aubrey | PK | Dal | 30 | **** | Questionable | Shoulder |
| Harrison Butker | PK | KC | 29 | **** | ||
| Laiatu Latu | DL | Ind | 24 | **** | Questionable | Shoulder |
| Arden Key | DL | Ten | N/A | **** | Questionable | Hand |
| Harold Landry | DL | Ten | 28 | **** | ||
| Leonard Williams | DL | Sea | 30 | **** | ||
| Kwity Paye | DL | Ind | 26 | **** | ||
| Troy Andersen | LB | Atl | 26 | **** | Questionable | Knee |
| Dorian Williams | LB | Buf | 23 | **** | ||
| Jordyn Brooks | LB | Mia | 27 | **** | Questionable | Wrist |
| Christian Rozeboom | LB | LAR | N/A | **** | ||
| Frankie Luvu | LB | Was | 28 | **** | ||
| Payton Wilson | LB | Pit | 25 | **** | ||
| Chamarri Conner | CB | KC | N/A | **** | ||
| DaRon Bland | CB | Dal | 25 | **** | ||
| Jaylon Jones | CB | Ind | N/A | **** | ||
| Brian Branch | S | Det | 23 | **** | ||
| Julian Blackmon | S | Ind | 26 | **** |