| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Bo Nix | QB | Den | 25 | **** | ||
| Jayden Daniels | QB | Was | 24 | **** | ||
| Matthew Stafford | QB | LAR | 37 | **** | ||
| Tank Bigsby | RB | Jac | 23 | **** | ||
| Kimani Vidal | RB | LAC | 23 | **** | ||
| Isaac Guerendo | RB | SF | 24 | **** | Questionable | Knee - MCL |
| Gus Edwards | RB | LAC | 30 | **** | ||
| Josh Jacobs | RB | GB | 27 | **** | ||
| David Montgomery | RB | Det | 27 | **** | ||
| Brandon Aiyuk | WR | SF | 27 | **** | Questionable | Knee - ACL + MCL |
| Courtland Sutton | WR | Den | 29 | **** | ||
| DeVonta Smith | WR | Phi | 26 | **** | ||
| Jameson Williams | WR | Det | 24 | **** | ||
| Luke McCaffrey | WR | Was | 24 | **** | ||
| Adonai Mitchell | WR | Ind | 22 | **** | ||
| Demario Douglas | WR | NE | 24 | **** | ||
| Jaxon Smith-Njigba | WR | Sea | 23 | **** | ||
| Marvin Mims | WR | Den | 23 | **** | ||
| Tucker Kraft | TE | GB | N/A | **** | ||
| Sam LaPorta | TE | Det | 24 | **** | ||
| Taysom Hill | TE | NO | 34 | **** | Questionable | Knee - ACL |
| Cameron Dicker | PK | LAC | 24 | **** | ||
| Jake Moody | PK | SF | 25 | **** | ||
| Kobie Turner | DL | LAR | N/A | **** | ||
| Leonard Williams | DL | Sea | 30 | **** | ||
| Tyrice Knight | LB | Sea | 24 | **** | ||
| Edgerrin Cooper | LB | GB | 23 | **** | ||
| Fred Warner | LB | SF | 28 | **** | ||
| Kyzir White | LB | Ari | 29 | **** | ||
| Logan Wilson | LB | Cin | 28 | **** | Questionable | Knee |
| Akeem Davis-Gaither | LB | Cin | N/A | **** | ||
| DeMarvion Overshown | LB | Dal | 24 | **** | Questionable | Knee - ACL + MCL |
| Daiyan Henley | LB | LAC | N/A | **** | Questionable | Shoulder - Labrum |