| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Kirk Cousins | QB | Atl | 36 | **** | ||
| Patrick Mahomes | QB | KC | 29 | **** | ||
| Joe Burrow | QB | Cin | 28 | **** | ||
| Jonathan Taylor | RB | Ind | 26 | **** | ||
| Cam Akers | RB | Min | 25 | **** | ||
| Antonio Gibson | RB | NE | 26 | **** | ||
| Alexander Mattison | RB | Mia | 26 | **** | ||
| Tyler Allgeier | RB | Atl | 25 | **** | ||
| Christian McCaffrey | RB | SF | 28 | **** | ||
| Isaac Guerendo | RB | SF | 24 | **** | Questionable | Knee - MCL |
| Devaughn Vele | WR | Den | 27 | **** | ||
| Amari Cooper | WR | Buf | 30 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| George Pickens | WR | Pit | 23 | **** | ||
| Michael Wilson | WR | Ari | 25 | **** | Questionable | Hamstring |
| Garrett Wilson | WR | NYJ | 24 | **** | ||
| David Njoku | TE | Cle | 28 | **** | Questionable | Knee |
| Jonnu Smith | TE | Mia | 29 | **** | ||
| Travis Kelce | TE | KC | 35 | **** | ||
| Chad Ryland | PK | Ari | N/A | **** | ||
| Maxx Crosby | DL | LV | 27 | **** | Questionable | Ankle |
| Dante Fowler | DL | Was | 30 | **** | ||
| A'Shawn Robinson | DL | Car | 30 | **** | Questionable | Calf |
| Jared Verse | DL | LAR | 24 | **** | ||
| Cameron Heyward | DL | Pit | 35 | **** | ||
| Fred Warner | LB | SF | 28 | **** | ||
| Zaire Franklin | LB | Ind | 28 | **** | ||
| Jahlani Tavai | LB | NE | 28 | **** | ||
| Devin Lloyd | LB | Jac | 26 | **** | ||
| Ernest Jones | LB | Sea | 25 | **** | Questionable | Knee |
| Nakobe Dean | LB | Phi | 24 | **** | Questionable | Knee |
| Christian Gonzalez | CB | NE | N/A | **** | Questionable | Concussion |
| Jaylon Jones | CB | Ind | N/A | **** | ||
| Derwin James | S | LAC | 28 | **** |