| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Deshaun Watson | QB | Cle | 29 | **** | Questionable | Achilles |
| Lamar Jackson | QB | Bal | 28 | **** | ||
| Joe Burrow | QB | Cin | 28 | **** | ||
| J.K. Dobbins | RB | LAC | 26 | **** | ||
| Justice Hill | RB | Bal | 27 | **** | ||
| Kareem Hunt | RB | KC | 29 | **** | ||
| Raheem Mostert | RB | LV | 33 | **** | ||
| Kenneth Walker | RB | Sea | 24 | **** | Questionable | Ankle |
| Zamir White | RB | LV | 25 | **** | ||
| Jordan Mason | RB | Min | 25 | **** | Questionable | Ankle |
| Tank Bigsby | RB | Jac | 23 | **** | ||
| Chase Brown | RB | Cin | 25 | **** | Questionable | Ankle |
| Emanuel Wilson | RB | GB | 25 | **** | ||
| Michael Wilson | WR | Ari | 25 | **** | Questionable | Hamstring |
| Jaxon Smith-Njigba | WR | Sea | 23 | **** | ||
| Quentin Johnston | WR | LAC | 23 | **** | ||
| Jalen Nailor | WR | Min | N/A | **** | ||
| Deebo Samuel | WR | SF | 29 | **** | ||
| Ja'Marr Chase | WR | Cin | 25 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Marvin Harrison Jr. | WR | Ari | 22 | **** | ||
| Jalen Coker | WR | Car | 23 | **** | ||
| Davante Adams | WR | LAR | 32 | **** | ||
| Ja'Tavion Sanders | TE | Car | 22 | **** | ||
| Andrew Van Ginkel | DL | Min | 29 | **** | ||
| Harold Landry | DL | Ten | 28 | **** | ||
| Will Anderson | DL | Hou | 23 | **** | ||
| Kobie Turner | DL | LAR | N/A | **** | ||
| Nolan Smith | LB | Phi | N/A | **** | Questionable | Triceps |
| Foyesade Oluokun | LB | Jac | 29 | **** | ||
| Frankie Luvu | LB | Was | 28 | **** | ||
| Robert Spillane | LB | LV | 29 | **** | ||
| Akeem Davis-Gaither | LB | Cin | N/A | **** |