| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Caleb Williams | QB | Chi | 23 | **** | Questionable | Wrist |
| Geno Smith | QB | LV | 34 | **** | ||
| Jameis Winston | QB | NYG | 31 | **** | ||
| David Montgomery | RB | Det | 27 | **** | ||
| Clyde Edwards-Helaire | RB | NO | 26 | **** | ||
| Jonathon Brooks | RB | Car | 21 | **** | Questionable | Knee - ACL |
| Kenneth Gainwell | RB | Pit | 26 | **** | ||
| Jerome Ford | RB | Cle | 25 | **** | Questionable | Ankle |
| Jaylen Warren | RB | Pit | 26 | **** | ||
| Chris Rodriguez | RB | Was | 24 | **** | ||
| Dontayvion Wicks | WR | GB | 23 | **** | ||
| Kayshon Boutte | WR | NE | N/A | **** | ||
| Rashod Bateman | WR | Bal | 25 | **** | ||
| Garrett Wilson | WR | NYJ | 24 | **** | ||
| Chris Olave | WR | NO | 24 | **** | Questionable | Concussion |
| D.J. Moore | WR | Chi | 28 | **** | ||
| Amari Cooper | WR | Buf | 30 | **** | ||
| Malik Washington | WR | Mia | 24 | **** | ||
| Ja'Lynn Polk | WR | NE | 23 | **** | Questionable | Shoulder |
| Malik Nabers | WR | NYG | 21 | **** | ||
| Jake Ferguson | TE | Dal | 26 | **** | ||
| Travon Walker | DL | Jac | 24 | **** | ||
| Danielle Hunter | DL | Hou | 30 | **** | ||
| Alex Highsmith | DL | Pit | 27 | **** | ||
| Nick Bosa | DL | SF | 27 | **** | ||
| Brian Burns | DL | NYG | 27 | **** | ||
| Tyrice Knight | LB | Sea | 24 | **** | ||
| Jordan Hicks | LB | Cle | 32 | **** | Questionable | Concussion |
| Quay Walker | LB | GB | 24 | **** | ||
| Nakobe Dean | LB | Phi | 24 | **** | Questionable | Knee |
| Marlon Humphrey | CB | Bal | 28 | **** | ||
| Taron Johnson | CB | Buf | 28 | **** | ||
| Brian Branch | S | Det | 23 | **** |