| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Jared Goff | QB | Det | 30 | **** | ||
| Brock Purdy | QB | SF | 25 | **** | ||
| Josh Jacobs | RB | GB | 27 | **** | ||
| Trey Sermon | RB | Ind | 26 | **** | ||
| Chuba Hubbard | RB | Car | 25 | **** | ||
| James Conner | RB | Ari | 29 | **** | Questionable | Knee |
| Stefon Diggs | WR | NE | 31 | **** | Questionable | Knee - ACL |
| Brian Thomas Jr. | WR | Jac | 22 | **** | ||
| Mike Evans | WR | TB | 31 | **** | ||
| Amari Cooper | WR | Buf | 30 | **** | ||
| Tyler Lockett | WR | Sea | 32 | **** | ||
| Kristian Wilkerson | WR | LV | N/A | **** | ||
| Cole Kmet | TE | Chi | 26 | **** | ||
| Dawson Knox | TE | Buf | 28 | **** | ||
| Brandon McManus | PK | GB | 33 | **** | ||
| Daniel Carlson | PK | LV | 30 | **** | ||
| Ka'imi Fairbairn | PK | Hou | 31 | **** | ||
| Laiatu Latu | DL | Ind | 24 | **** | Questionable | Shoulder |
| Grady Jarrett | DL | Chi | 32 | **** | ||
| Jonathan Greenard | DL | Min | 27 | **** | ||
| Boye Mafe | DL | Sea | 26 | **** | ||
| Jaquelin Roy | DL | NE | N/A | **** | Questionable | Foot |
| Azeez Al-Shaair | LB | Hou | 27 | **** | Questionable | Knee |
| Germaine Pratt | LB | Cin | 28 | **** | ||
| Kyle Van Noy | LB | Bal | 34 | **** | ||
| Lavonte David | LB | TB | 35 | **** | ||
| Josey Jewell | LB | Car | 30 | **** | Questionable | Concussion |
| Kyzir White | LB | Ari | 29 | **** | ||
| Taron Johnson | CB | Buf | 28 | **** | ||
| Marlon Humphrey | CB | Bal | 28 | **** | ||
| Nate Hobbs | CB | LV | 25 | **** | ||
| Kamren Curl | S | LAR | 26 | **** | ||
| Xavier McKinney | S | GB | 36 | **** |