| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Caleb Williams | QB | Chi | 23 | **** | Questionable | Wrist |
| Sam Darnold | QB | Sea | 27 | **** | ||
| Aaron Jones | RB | Min | 30 | **** | ||
| MarShawn Lloyd | RB | GB | 24 | **** | Questionable | Hamstring |
| D'Andre Swift | RB | Chi | 26 | **** | ||
| Rico Dowdle | RB | Car | 26 | **** | ||
| Travis Etienne | RB | Jac | 26 | **** | ||
| Bijan Robinson | RB | Atl | 23 | **** | ||
| Amon-Ra St. Brown | WR | Det | 25 | **** | ||
| Drake London | WR | Atl | 24 | **** | ||
| Ricky Pearsall | WR | SF | 24 | **** | ||
| DeAndre Hopkins | WR | Bal | 32 | **** | ||
| Demarcus Robinson | WR | SF | 30 | **** | ||
| Allen Lazard | WR | NYJ | 29 | **** | ||
| Theo Johnson | TE | NYG | 24 | **** | Questionable | Foot |
| Hunter Henry | TE | NE | 30 | **** | Questionable | Foot |
| Trey McBride | TE | Ari | 25 | **** | ||
| Chris Boswell | PK | Pit | 34 | **** | ||
| Danielle Hunter | DL | Hou | 30 | **** | ||
| Cameron Heyward | DL | Pit | 35 | **** | ||
| Braden Fiske | DL | LAR | 25 | **** | Questionable | Knee |
| Trey Hendrickson | DL | Cin | 30 | **** | ||
| Aidan Hutchinson | DL | Det | 24 | **** | Questionable | Lower leg |
| Nick Bolton | LB | KC | 25 | **** | ||
| Dorian Williams | LB | Buf | 23 | **** | ||
| Kenneth Murray | LB | Ten | 26 | **** | ||
| Roquan Smith | LB | Bal | 28 | **** | ||
| De'Vondre Campbell | LB | SF | 31 | **** | ||
| Carlton Davis | CB | Det | 28 | **** | ||
| Zyon McCollum | CB | TB | N/A | **** | ||
| Kerby Joseph | S | Det | 24 | **** |