| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Baker Mayfield | QB | TB | 30 | **** | ||
| Justin Herbert | QB | LAC | 27 | **** | ||
| Cam Akers | RB | Min | 25 | **** | ||
| Aaron Jones | RB | Min | 30 | **** | ||
| Alexander Mattison | RB | Mia | 26 | **** | ||
| Isaiah Davis | RB | NYJ | 23 | **** | ||
| Isaac Guerendo | RB | SF | 24 | **** | Questionable | Knee - MCL |
| Elijah Mitchell | RB | KC | 27 | **** | ||
| Khalil Herbert | RB | Ind | 27 | **** | ||
| Dameon Pierce | RB | Hou | 25 | **** | ||
| Ty Chandler | RB | Min | 26 | **** | ||
| Kendre Miller | RB | NO | 22 | **** | Questionable | Concussion |
| De'Von Achane | RB | Mia | 23 | **** | ||
| Emanuel Wilson | RB | GB | 25 | **** | ||
| George Pickens | WR | Pit | 23 | **** | ||
| Ja'Marr Chase | WR | Cin | 25 | **** | ||
| Nico Collins | WR | Hou | 26 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| D.J. Moore | WR | Chi | 28 | **** | ||
| Pat Freiermuth | TE | Pit | 26 | **** | ||
| Noah Gray | TE | KC | N/A | **** | ||
| Cade Otton | TE | TB | 26 | **** | ||
| Jake Elliott | PK | Phi | 30 | **** | ||
| Josh Sweat | DL | Ari | 28 | **** | ||
| Zach Allen | DL | Den | 27 | **** | ||
| Chop Robinson | DL | Mia | 22 | **** | ||
| Jonathan Greenard | DL | Min | 27 | **** | ||
| D.J. Wonnum | DL | Car | 27 | **** | ||
| Blake Cashman | LB | Min | 28 | **** | ||
| Jamien Sherwood | LB | NYJ | 25 | **** | ||
| Nakobe Dean | LB | Phi | 24 | **** | Questionable | Knee |
| Zyon McCollum | CB | TB | N/A | **** | ||
| Brandon Jones | S | Den | 27 | **** |