| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Justin Herbert | QB |
|
28 | No More Bye | Questionable | Finger |
| Patrick Mahomes | QB |
|
31 | No More Bye | Questionable | Elbow |
| Blake Corum | RB |
|
25 | Week 11 | ||
| Jacory Croskey-Merritt | RB |
|
25 | No More Bye | NFI | Groin |
| Cam Skattebo | RB |
|
24 | No More Bye | Questionable | Hamstring |
| Jonathan Taylor | RB |
|
27 | Week 13 | ||
| Kenneth Walker | RB |
|
26 | No More Bye | ||
| Jalen Coker | WR |
|
25 | No More Bye | ||
| KC Concepcion | WR |
|
22 | Week 11 | ||
| Emeka Egbuka | WR |
|
24 | Week 10 | ||
| Tre Harris | WR |
|
24 | No More Bye | ||
| Drake London | WR |
|
26 | Week 11 | ||
| Demarcus Robinson | WR |
|
32 | No More Bye | ||
| Deebo Samuel | WR |
|
30 | No More Bye | Questionable | Hamstring |
| Antonio Williams | WR |
|
22 | No More Bye | ||
| Hunter Henry | TE |
|
31 | Week 11 | ||
| Tucker Kraft | TE |
|
N/A | Week 11 | ||
| Spencer Shrader | PK |
|
27 | Week 13 | ||
| Will Anderson | DL |
|
25 | No More Bye | ||
| Abdul Carter | DL |
|
22 | No More Bye | Questionable | Knee |
| Josh Hines-Allen | DL |
|
29 | No More Bye | ||
| George Karlaftis | DL |
|
25 | No More Bye | ||
| Daiyan Henley | LB |
|
N/A | No More Bye | ||
| Shemar James | LB |
|
22 | Week 14 | ||
| Isaiah McDuffie | LB |
|
27 | Week 11 | ||
| Bobby Okereke | LB |
|
30 | No More Bye | Questionable | Foot |
| Josiah Trotter | LB |
|
21 | Week 10 | ||
| Mack Wilson | LB |
|
28 | Week 14 | ||
| Mansoor Delane | CB |
|
22 | No More Bye | Questionable | Shoulder |
| Kyler Gordon | CB |
|
26 | Week 10 | ||
| CJ Henderson | CB |
|
28 | Week 11 | ||
| Budda Baker | S |
|
30 | Week 14 | ||
| Quentin Lake | S |
|
N/A | Week 11 |