| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Jacoby Brissett | QB |
|
33 | Week 13 | ||
| Caleb Williams | QB |
|
24 | Week 10 | ||
| Braelon Allen | RB |
|
22 | Week 13 | ||
| Jonah Coleman | RB |
|
23 | Week 10 | ||
| J.K. Dobbins | RB |
|
27 | Week 10 | ||
| Austin Ekeler | RB |
|
31 | No More Bye | ||
| RJ Harvey | RB |
|
25 | Week 10 | NFI | Knee |
| Emmett Johnson | RB |
|
23 | No More Bye | ||
| MarShawn Lloyd | RB |
|
25 | Week 11 | Questionable | Knee |
| Jordan Mason | RB |
|
27 | No More Bye | ||
| Keenan Allen | WR |
|
34 | Week 13 | ||
| Caleb Douglas | WR |
|
23 | No More Bye | ||
| Justin Jefferson | WR |
|
27 | No More Bye | ||
| CeeDee Lamb | WR |
|
27 | Week 14 | ||
| Malik Nabers | WR |
|
23 | No More Bye | ||
| DeVonta Smith | WR |
|
27 | Week 10 | Questionable | Hamstring |
| Jordyn Tyson | WR |
|
22 | No More Bye | ||
| Devaughn Vele | WR |
|
28 | No More Bye | ||
| T.J. Hockenson | TE |
|
29 | No More Bye | ||
| Darren Waller | TE |
|
34 | No More Bye | ||
| Chase McLaughlin | PK |
|
30 | Week 10 | ||
| Zaven Collins | DL |
|
27 | Week 14 | ||
| Mason Graham | DL |
|
23 | Week 11 | ||
| Jarrian Jones | DL |
|
25 | No More Bye | ||
| Malcolm Roach | DL |
|
N/A | Week 10 | ||
| Charles Woods | DL |
|
26 | Week 11 | Questionable | Hamstring |
| CJ Allen | LB |
|
21 | Week 13 | ||
| Derrick Barnes | LB |
|
27 | No More Bye | ||
| Kendal Daniels | LB |
|
23 | Week 11 | ||
| Foyesade Oluokun | LB |
|
31 | No More Bye | ||
| Deonte Banks | CB |
|
N/A | No More Bye | ||
| Keisean Nixon | CB |
|
N/A | Week 11 | ||
| Xavier McKinney | S |
|
38 | Week 11 |