| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Justin Herbert | QB |
|
28 | No More Bye | Questionable | Finger |
| Joe Milton III | QB |
|
26 | Week 10 | ||
| Deshaun Watson | QB |
|
31 | Week 11 | Questionable | Concussion |
| Carson Wentz | QB |
|
33 | No More Bye | ||
| Zach Charbonnet | RB |
|
25 | Week 11 | ||
| J.K. Dobbins | RB |
|
27 | Week 10 | ||
| Jahmyr Gibbs | RB |
|
24 | No More Bye | ||
| Justice Hill | RB |
|
28 | Week 13 | ||
| Seth McGowan | RB |
|
25 | Week 13 | ||
| Nicholas Singleton | RB |
|
22 | No More Bye | ||
| Cam Skattebo | RB |
|
24 | No More Bye | Questionable | Hamstring |
| Mike Washington Jr. | RB |
|
23 | Week 13 | ||
| Keenan Allen | WR |
|
34 | Week 13 | ||
| Germie Bernard | WR |
|
22 | No More Bye | ||
| Luther Burden III | WR |
|
22 | Week 10 | Questionable | Concussion |
| Omar Cooper Jr. | WR |
|
22 | Week 13 | ||
| Chris Olave | WR |
|
26 | No More Bye | ||
| George Pickens | WR |
|
24 | Week 14 | Questionable | Hamstring |
| Michael Wilson | WR |
|
26 | Week 14 | Out | Neck |
| Harold Fannin Jr. | TE |
|
22 | Week 11 | ||
| Tyler Higbee | TE |
|
33 | Week 11 | ||
| Cam Little | PK |
|
23 | No More Bye | ||
| Lukas Van Ness | DL |
|
25 | Week 11 | ||
| Leonard Williams | DL |
|
32 | Week 11 | Questionable | Shoulder |
| Charles Woods | DL |
|
26 | Week 11 | Questionable | Hamstring |
| Kendal Daniels | LB |
|
23 | Week 11 | ||
| Zaire Franklin | LB |
|
30 | Week 11 | Doubtful | Shin |
| Jacob Rodriguez | LB |
|
24 | No More Bye | ||
| Trenton Simpson | LB |
|
25 | Week 13 | ||
| Drake Thomas | LB |
|
N/A | Week 11 | ||
| Jacob Parrish | CB |
|
22 | Week 10 | ||
| Amik Robertson | CB |
|
N/A | No More Bye | ||
| Evan Williams | S |
|
25 | Week 11 |