| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Jared Goff | QB | Det | 30 | **** | ||
| Jordan Love | QB | GB | 26 | **** | ||
| Trey Lance | QB | Dal | 24 | **** | ||
| Chuba Hubbard | RB | Car | 25 | **** | ||
| Bijan Robinson | RB | Atl | 23 | **** | ||
| Kendre Miller | RB | NO | 22 | **** | Questionable | Concussion |
| Chris Rodriguez | RB | Was | 24 | **** | ||
| Emari Demercado | RB | Ari | 26 | **** | Questionable | Back |
| Keaton Mitchell | RB | Bal | 23 | **** | ||
| Cam Akers | RB | Min | 25 | **** | ||
| Patrick Taylor | RB | SF | 27 | **** | ||
| Christian McCaffrey | RB | SF | 28 | **** | ||
| Nick Chubb | RB | Cle | 29 | **** | ||
| Audric Estime | RB | Den | 21 | **** | ||
| Dylan Laube | RB | LV | 25 | **** | ||
| Blake Corum | RB | LAR | 24 | **** | Questionable | Forearm |
| Ja'Lynn Polk | WR | NE | 23 | **** | Questionable | Shoulder |
| Ricky Pearsall | WR | SF | 24 | **** | ||
| DeAndre Hopkins | WR | Bal | 32 | **** | ||
| Keenan Allen | WR | Chi | 33 | **** | ||
| Cooper Kupp | WR | Sea | 31 | **** | ||
| Calvin Austin | WR | Pit | 26 | **** | ||
| Garrett Wilson | WR | NYJ | 24 | **** | ||
| Noah Gray | TE | KC | N/A | **** | ||
| Sam LaPorta | TE | Det | 24 | **** | ||
| David Njoku | TE | Cle | 28 | **** | Questionable | Knee |
| Ja'Tavion Sanders | TE | Car | 22 | **** | ||
| Justin Tucker | PK | Bal | 35 | **** | ||
| Andrew Van Ginkel | DL | Min | 29 | **** | ||
| Tuli Tuipulotu | DL | LAC | 22 | **** | ||
| Troy Andersen | LB | Atl | 26 | **** | Questionable | Knee |
| Zyon McCollum | CB | TB | N/A | **** | ||
| Julian Blackmon | S | Ind | 26 | **** |