| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | LV | 34 | **** | ||
| Kyler Murray | QB | Ari | 27 | **** | ||
| Josh Jacobs | RB | GB | 27 | **** | ||
| Dalvin Cook | RB | Dal | 29 | **** | ||
| Kareem Hunt | RB | KC | 29 | **** | ||
| MarShawn Lloyd | RB | GB | 24 | **** | Questionable | Hamstring |
| Travis Etienne | RB | Jac | 26 | **** | ||
| De'Von Achane | RB | Mia | 23 | **** | ||
| Zach Charbonnet | RB | Sea | 24 | **** | ||
| Tre Tucker | WR | LV | N/A | **** | ||
| Darnell Mooney | WR | Atl | 27 | **** | Questionable | Shoulder |
| Troy Franklin | WR | Den | 22 | **** | ||
| Ladd McConkey | WR | LAC | 23 | **** | ||
| Adam Thielen | WR | Car | 34 | **** | ||
| Amari Cooper | WR | Buf | 30 | **** | ||
| Courtland Sutton | WR | Den | 29 | **** | ||
| Theo Johnson | TE | NYG | 24 | **** | Questionable | Foot |
| Tucker Kraft | TE | GB | N/A | **** | ||
| Chad Ryland | PK | Ari | N/A | **** | ||
| Tuli Tuipulotu | DL | LAC | 22 | **** | ||
| Keion White | DL | NE | N/A | **** | ||
| Boye Mafe | DL | Sea | 26 | **** | ||
| Leonard Williams | DL | Sea | 30 | **** | ||
| Jeffery Simmons | DL | Ten | 27 | **** | ||
| Mack Wilson | LB | Ari | 27 | **** | ||
| Jordyn Brooks | LB | Mia | 27 | **** | Questionable | Wrist |
| Jerome Baker | LB | Ten | 28 | **** | ||
| Terrel Bernard | LB | Buf | 25 | **** | ||
| Nate Landman | LB | Atl | 26 | **** | ||
| Tyrique Stevenson | CB | Chi | 24 | **** | ||
| Chamarri Conner | CB | KC | N/A | **** | ||
| Jaquan Brisker | S | Chi | 26 | **** | Questionable | Concussion |
| Camryn Bynum | S | Min | 26 | **** |