| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Geno Smith | QB | LV | 34 | **** | ||
| Kyler Murray | QB | Ari | 27 | **** | ||
| Justice Hill | RB | Bal | 27 | **** | ||
| AJ Dillon | RB | GB | 27 | **** | ||
| Antonio Gibson | RB | NE | 26 | **** | ||
| Patrick Taylor | RB | SF | 27 | **** | ||
| Trey Sermon | RB | Ind | 26 | **** | ||
| Khalil Herbert | RB | Ind | 27 | **** | ||
| De'Von Achane | RB | Mia | 23 | **** | ||
| Jaleel McLaughlin | RB | Den | 24 | **** | ||
| Isaac Guerendo | RB | SF | 24 | **** | Questionable | Knee - MCL |
| Samaje Perine | RB | Cin | 29 | **** | ||
| Ja'Lynn Polk | WR | NE | 23 | **** | Questionable | Shoulder |
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Noah Brown | WR | Was | 29 | **** | ||
| Calvin Ridley | WR | Ten | 30 | **** | ||
| Courtland Sutton | WR | Den | 29 | **** | ||
| DeAndre Hopkins | WR | Bal | 32 | **** | ||
| Stefon Diggs | WR | NE | 31 | **** | Questionable | Knee - ACL |
| Wan'Dale Robinson | WR | NYG | 24 | **** | ||
| Cedric Tillman | WR | Cle | 25 | **** | Questionable | Concussion |
| Hunter Henry | TE | NE | 30 | **** | Questionable | Foot |
| Dallas Goedert | TE | Phi | 30 | **** | ||
| George Kittle | TE | SF | 31 | **** | ||
| Chris Boswell | PK | Pit | 34 | **** | ||
| Chris Jones | DL | KC | 30 | **** | ||
| A'Shawn Robinson | DL | Car | 30 | **** | Questionable | Calf |
| Zach Sieler | DL | Mia | 29 | **** | ||
| Dorian Williams | LB | Buf | 23 | **** | ||
| T.J. Edwards | LB | Chi | 28 | **** | ||
| Fred Warner | LB | SF | 28 | **** | ||
| Kyzir White | LB | Ari | 29 | **** | ||
| Julian Love | S | Sea | 27 | **** |