| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Sam Darnold | QB | Min | 26 | Week 6 | ||
| Jordan Love | QB | GB | 25 | Week 10 | ||
| Trey Lance | QB | Dal | 24 | Week 7 | ||
| Brock Purdy | QB | SF | 24 | Week 9 | ||
| Jerome Ford | RB | Cle | N/A | Week 10 | ||
| Kyren Williams | RB | LAR | N/A | Week 6 | ||
| Tank Bigsby | RB | Jac | 22 | Week 12 | ||
| Rico Dowdle | RB | Dal | 25 | Week 7 | ||
| Zamir White | RB | LV | 24 | Week 10 | ||
| Travis Etienne | RB | Jac | 25 | Week 12 | ||
| D'Ernest Johnson | RB | Jac | 28 | Week 12 | ||
| Josh Jacobs | RB | GB | 26 | Week 10 | ||
| Deebo Samuel | WR | SF | 28 | Week 9 | ||
| Jerry Jeudy | WR | Cle | 25 | Week 10 | ||
| Khalil Shakir | WR | Buf | 24 | Week 12 | ||
| Drake London | WR | Atl | 23 | Week 12 | ||
| Dontayvion Wicks | WR | GB | N/A | Week 10 | ||
| Quentin Johnston | WR | LAC | 22 | Week 5 | ||
| Sam LaPorta | TE | Det | 23 | Week 5 | ||
| Trey McBride | TE | Ari | 24 | Week 11 | ||
| Pat Freiermuth | TE | Pit | 25 | Week 9 | ||
| Jake Moody | PK | SF | 24 | Week 9 | ||
| Jermaine Johnson | DL | NYJ | N/A | Week 12 | ||
| Christian Wilkins | DL | Mia | 28 | Week 6 | ||
| Maxx Crosby | DL | LV | 26 | Week 10 | ||
| Andrew Van Ginkel | DL | Min | N/A | Week 6 | ||
| Fred Warner | LB | SF | 27 | Week 9 | ||
| Kyzir White | LB | Ari | 28 | Week 11 | ||
| Devin White | LB | Phi | 26 | Week 5 | ||
| Logan Wilson | LB | Cin | 27 | Week 12 | ||
| Quay Walker | LB | GB | 24 | Week 10 | ||
| Christian Harris | LB | Hou | N/A | Week 14 | ||
| Kenny Moore | CB | Ind | 28 | Week 14 | ||
| Julian Blackmon | S | Ind | N/A | Week 14 |