| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Deshaun Watson | QB | Cle | 29 | **** | Questionable | Achilles |
| Sam Darnold | QB | Sea | 27 | **** | ||
| Kyler Murray | QB | Ari | 27 | **** | ||
| Anthony Richardson | QB | Ind | 22 | **** | Questionable | Back |
| Jordan Mason | RB | Min | 25 | **** | Questionable | Ankle |
| Sincere McCormick | RB | LV | N/A | **** | ||
| Keaton Mitchell | RB | Bal | 23 | **** | ||
| Dameon Pierce | RB | Hou | 25 | **** | ||
| Justice Hill | RB | Bal | 27 | **** | ||
| Christian McCaffrey | RB | SF | 28 | **** | ||
| Gus Edwards | RB | LAC | 30 | **** | ||
| AJ Dillon | RB | GB | 27 | **** | ||
| Zack Moss | RB | Cin | 27 | **** | Questionable | Neck |
| Joe Mixon | RB | Hou | 28 | **** | ||
| Derrick Henry | RB | Bal | 30 | **** | ||
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| Mike Williams | WR | LAC | 30 | **** | ||
| Malik Washington | WR | Mia | 24 | **** | ||
| Ladd McConkey | WR | LAC | 23 | **** | ||
| Xavier Legette | WR | Car | 24 | **** | Questionable | Foot |
| Tee Higgins | WR | Cin | 26 | **** | ||
| Jaylen Waddle | WR | Mia | 26 | **** | ||
| Cade Otton | TE | TB | 26 | **** | ||
| Dalton Kincaid | TE | Buf | 26 | **** | ||
| Micah Parsons | DL | Dal | 26 | **** | ||
| Kayvon Thibodeaux | DL | NYG | 24 | **** | ||
| Harold Landry | DL | Ten | 28 | **** | ||
| Alex Highsmith | DL | Pit | 27 | **** | ||
| Blake Cashman | LB | Min | 28 | **** | ||
| E.J. Speed | LB | Ind | 29 | **** | ||
| Kaden Elliss | LB | Atl | 29 | **** | ||
| Alontae Taylor | CB | NO | N/A | **** | ||
| Dane Belton | S | NYG | N/A | **** |