| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Patrick Mahomes | QB | KC | 29 | **** | ||
| Trevor Lawrence | QB | Jac | 25 | **** | Questionable | Shoulder - AC Joint |
| Dalvin Cook | RB | Dal | 29 | **** | ||
| Ezekiel Elliott | RB | Dal | 29 | **** | ||
| Rhamondre Stevenson | RB | NE | 27 | **** | ||
| Chuba Hubbard | RB | Car | 25 | **** | ||
| J.K. Dobbins | RB | LAC | 26 | **** | ||
| Isiah Pacheco | RB | KC | 26 | **** | ||
| Jordan Addison | WR | Min | 23 | **** | ||
| Josh Downs | WR | Ind | 23 | **** | ||
| Alec Pierce | WR | Ind | 25 | **** | ||
| Nico Collins | WR | Hou | 26 | **** | ||
| Keenan Allen | WR | Chi | 33 | **** | ||
| Rome Odunze | WR | Chi | 22 | **** | ||
| Ja'Lynn Polk | WR | NE | 23 | **** | Questionable | Shoulder |
| Xavier Legette | WR | Car | 24 | **** | Questionable | Foot |
| Evan Engram | TE | Den | 30 | **** | Questionable | Shoulder - Labrum |
| Michael Mayer | TE | LV | 23 | **** | ||
| Evan McPherson | PK | Cin | 25 | **** | Questionable | Groin |
| Harrison Butker | PK | KC | 29 | **** | ||
| Kwity Paye | DL | Ind | 26 | **** | ||
| Christian Wilkins | DL | LV | 29 | **** | Questionable | Foot |
| Jadeveon Clowney | DL | Car | 32 | **** | ||
| Patrick Jones II | DL | Min | 26 | **** | ||
| Jordan Hicks | LB | Cle | 32 | **** | Questionable | Concussion |
| Lavonte David | LB | TB | 35 | **** | ||
| Demario Davis | LB | NO | 36 | **** | ||
| Germaine Pratt | LB | Cin | 28 | **** | ||
| Tremaine Edmunds | LB | Chi | 27 | **** | ||
| Nate Hobbs | CB | LV | 25 | **** | ||
| Tyrique Stevenson | CB | Chi | 24 | **** | ||
| Minkah Fitzpatrick | S | Pit | 28 | **** | ||
| Antoine Winfield | S | TB | 26 | **** |