| Name | Pos | Team | Age | Bye Week | Health | Injury |
|---|---|---|---|---|---|---|
| Justin Herbert | QB | LAC | 27 | **** | ||
| Jalen Hurts | QB | Phi | 26 | **** | ||
| Chuba Hubbard | RB | Car | 25 | **** | ||
| Nick Chubb | RB | Cle | 29 | **** | ||
| Raheem Blackshear | RB | Car | N/A | **** | ||
| De'Von Achane | RB | Mia | 23 | **** | ||
| Raheem Mostert | RB | LV | 33 | **** | ||
| Alvin Kamara | RB | NO | 29 | **** | Questionable | Groin |
| Tyreek Hill | WR | Mia | 31 | **** | Questionable | Wrist |
| D.J. Moore | WR | Chi | 28 | **** | ||
| Keon Coleman | WR | Buf | 21 | **** | ||
| Ladd McConkey | WR | LAC | 23 | **** | ||
| Jayden Reed | WR | GB | 25 | **** | Questionable | Shoulder |
| Justin Jefferson | WR | Min | 26 | **** | ||
| Travis Kelce | TE | KC | 35 | **** | ||
| Brock Bowers | TE | LV | 22 | **** | ||
| Jake Bates | PK | Det | 26 | **** | ||
| Harrison Butker | PK | KC | 29 | **** | ||
| Trey Hendrickson | DL | Cin | 30 | **** | ||
| Grover Stewart | DL | Ind | N/A | **** | ||
| A'Shawn Robinson | DL | Car | 30 | **** | Questionable | Calf |
| Cameron Heyward | DL | Pit | 35 | **** | ||
| Braden Fiske | DL | LAR | 25 | **** | Questionable | Knee |
| Calijah Kancey | DL | TB | N/A | **** | ||
| Keion White | DL | NE | N/A | **** | ||
| Christian Harris | LB | Hou | N/A | **** | ||
| Pete Werner | LB | NO | 25 | **** | Questionable | Concussion |
| Omar Speights | LB | LAR | 24 | **** | ||
| Eric Kendricks | LB | Dal | 33 | **** | ||
| Tremaine Edmunds | LB | Chi | 27 | **** | ||
| Riley Moss | CB | Den | N/A | **** | ||
| DaRon Bland | CB | Dal | 25 | **** | ||
| Nick Cross | S | Ind | N/A | **** | ||
| DeShon Elliott | S | Pit | N/A | **** |