| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | 42.84 | 24.01 | 384.24 | 446 Pass, 10 Rush, 4 TD |
| RB | Josh Jacobs | LV | 16.00 | 12.83 | 179.60 | 63 Rush, 17 Receiving, 4 Rec, 1 TD |
| RB | Ronald Jones | TB | 3.20 | 4.76 | 76.20 | 26 Rush, 1 Receiving, 1 Rec |
| WR | Ja'Marr Chase | Cin | 50.10 | 16.34 | 261.50 | 266 Receiving, 11 Rec, 3 TD |
| WR | Cooper Kupp | LAR | 18.50 | 21.49 | 343.90 | 95 Receiving, 6 Rec, 1 TD |
| WR | Cordarrelle Patterson | Atl | 6.20 | 13.79 | 206.90 | 28 Rush, 24 Receiving, 2 Rec |
| TE | Rob Gronkowski | TB | 15.00 | 11.50 | 126.50 | 115 Receiving, 7 Rec |
| HB | Devonta Freeman | Bal | 8.20 | 7.87 | 125.90 | 76 Rush, 1 Receiving, 1 Rec |
| PK | Nicholas Folk | NE | 8.00 | 9.94 | 159.00 | 1 FG(40-49), 5 XP, 1 Miss(<40) |
| DL | Dorance Armstrong | Dal | 10.00 | 5.17 | 62.00 | 3 Tackles, 2 Assists, 1.0 Sack, 1 PD |
| DL | Trey Hendrickson | Cin | 0.00 | 6.19 | 99.00 | Played, No Stats |
| DL | Da'Ron Payne | Was | 3.00 | 4.75 | 76.00 | 2 Tackles, 1 Assist |
| LB | Kamu Grugier-Hill | Hou | 7.00 | 9.92 | 129.00 | 5 Tackles, 2 Assists |
| LB | Shaquille Leonard | Ind | 16.00 | 11.53 | 173.00 | 6 Tackles, 1 Assist, 1 Int, 1 FF, 1 PD |
| LB | Shaq Thompson | Car | 7.00 | 9.31 | 121.00 | 4 Tackles, 3 Assists |
| CB | Taron Johnson | Buf | 8.00 | 6.67 | 100.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| S | Harrison Smith | Min | 8.00 | 9.64 | 135.00 | 5 Tackles, 3 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tua Tagovailoa | Mia | 0(5.30) | 16.65 | 199.76 | 205 Pass, 1 Rush, 1 Int, 1 Fumb |
| RB | Boston Scott | Phi | 0(22.60) | 5.82 | 93.10 | 47 Rush, 39 Receiving, 4 Rec, 2 TD |
| WR | A.J. Green | Ari | 0(8.90) | 8.37 | 125.50 | 74 Receiving, 3 Rec |
| TE | Tyler Conklin | Min | 0(7.20) | 6.64 | 106.20 | 47 Receiving, 5 Rec |
| WR | Kenny Golladay | NYG | 0 | 5.15 | 66.90 | Played, No Stats |
| PK | Dustin Hopkins | LAC | 0(10.00) | 8.50 | 136.00 | 2 FG(<40), 4 XP |
| DL | Shelby Harris | Den | 0(4.00) | 4.80 | 72.00 | 1 Tackle, 3 Assists |
| LB | Chris Kirksey | Hou | 0(10.00) | 8.75 | 105.00 | 5 Tackles, 4 Assists, 1 PD |
| CB | Anthony Brown | Dal | 0(4.00) | 7.00 | 112.00 | 2 Tackles, 2 PD |
| S | Jessie Bates | Cin | 0(5.00) | 6.53 | 98.00 | 2 Tackles, 2 Assists, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| RB | Myles Gaskin | Mia | 0(2.30) | 9.23 | 147.60 | 23 Rush |
| RB | Alexander Mattison | Min | 0(3.30) | 7.22 | 108.30 | 13 Receiving, 4 Rec |
| LB | Anthony Barr | Min | 0(9.00) | 8.90 | 89.00 | 5 Tackles, 4 Assists |
| Offense = 168.04 Defense = 59 Total = 227.04 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Tony Jones | NO | -0.20 | 1.74 | 17.40 | - 2 Rush |
| WR | Jamison Crowder | NYJ | DNP | 7.55 | 83.10 | Did Not Play |
| DL | Carlos Dunlap | Sea | 1.00 | 4.13 | 66.00 | 1 Tackle |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | James Robinson | Jac | DNP | 11.46 | 160.40 | Did Not Play |