| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Patrick Mahomes | KC | 24.86 | 25.59 | 409.46 | 259 Pass, 25 Rush, 2 TD |
| RB | Najee Harris | Pit | 28.10 | 16.01 | 256.20 | 188 Rush, 18 Receiving, 3 Rec, 1 TD |
| RB | Dare Ogunbowale | Jac | 13.80 | 2.29 | 36.60 | 36 Rush, 32 Receiving, 2 Rec, 1 TD |
| WR | A.J. Brown | Ten | 5.10 | 11.22 | 134.60 | 41 Receiving, 2 Rec |
| WR | Ja'Marr Chase | Cin | 50.10 | 16.34 | 261.50 | 266 Receiving, 11 Rec, 3 TD |
| WR | D.J. Moore | Car | 4.40 | 11.03 | 176.50 | 29 Receiving, 3 Rec |
| TE | Tyler Higbee | LAR | 9.90 | 6.40 | 96.00 | 69 Receiving, 6 Rec |
| HB | Marquez Valdes-Scantling | GB | 0.80 | 7.40 | 74.00 | 3 Receiving, 1 Rec |
| PK | Greg Zuerlein | Dal | 2.00 | 8.27 | 124.00 | 2 XP |
| DL | Jadeveon Clowney | Cle | 17.00 | 5.31 | 69.00 | 4 Tackles, 2 Assists, 2.0 Sacks, 1 FF |
| DL | Randy Gregory | Dal | 5.00 | 5.36 | 59.00 | 3 Tackles, 2 Assists |
| DL | Yannick Ngakoue | LV | 5.00 | 4.75 | 76.00 | 1 Tackle, 1.0 Sack |
| LB | Bobby Okereke | Ind | 11.00 | 9.31 | 149.00 | 10 Tackles, 1 Assist |
| LB | Troy Reeder | LAR | 14.00 | 6.44 | 103.00 | 6 Tackles, 4 Assists, 1.0 Sack |
| LB | Robert Spillane | Pit | 8.00 | 4.21 | 59.00 | 4 Tackles, 4 Assists |
| CB | Eric Murray | Hou | 9.00 | 5.33 | 80.00 | 6 Tackles, 2 Assists, 1 PD |
| S | Divine Deablo | LV | 10.00 | 2.63 | 42.00 | 9 Tackles, 1 PD |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Ryan Tannehill | Ten | 0(17.50) | 17.44 | 279.08 | 120 Pass, 7 Rush, 2 TD |
| RB | Tony Pollard | Dal | 0(7.30) | 9.54 | 143.10 | 9 Rush, 49 Receiving, 3 Rec |
| WR | Tyler Boyd | Cin | 0(11.60) | 9.40 | 150.34 | 36 Receiving, 4 Rec, 1 TD |
| TE | Foster Moreau | LV | 0(1.40) | 4.02 | 64.30 | 9 Receiving, 1 Rec |
| RB | Justin Jackson | LAC | 0(7.60) | 5.71 | 74.20 | 41 Rush, 20 Receiving, 3 Rec |
| PK | Dustin Hopkins | LAC | 0(10.00) | 8.50 | 136.00 | 2 FG(<40), 4 XP |
| DL | Zach Allen | Ari | 0(3.00) | 4.60 | 69.00 | 1 Tackle, 1 Assist, 1 PD |
| LB | Jeremiah Owusu-Koramoah | Cle | 0(7.00) | 6.85 | 89.00 | 3 Tackles, 4 Assists |
| CB | Taron Johnson | Buf | 0(8.00) | 6.67 | 100.00 | 3 Tackles, 1 Assist, 1.0 Sack |
| S | Harrison Smith | Min | 0(8.00) | 9.64 | 135.00 | 5 Tackles, 3 Assists |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| DL | Kenny Clark | GB | 0(1.00) | 4.07 | 61.00 | 1 Tackle |
| LB | Robert Quinn | Chi | 0(8.00) | 8.33 | 125.00 | 1 Tackle, 1.0 Sack, 1 FF |
| Offense = 139.06 Defense = 79 Total = 218.06 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| RB | Leonard Fournette | TB | DNP | 15.79 | 221.00 | Did Not Play |
| RB | Darrell Henderson | LAR | DNP | 12.41 | 148.90 | Did Not Play |
| RB | D'Ernest Johnson | Cle | 1.90 | 4.68 | 74.80 | 13 Rush, 1 Receiving, 1 Rec |
| TE | Darren Waller | LV | DNP | 10.28 | 102.80 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | James Robinson | Jac | DNP | 11.46 | 160.40 | Did Not Play |