| Pos. | Starters | Proteam | TW | PPG | Total | Breakdown |
| QB | Joe Burrow | Cin | 42.84 | 24.01 | 384.24 | 446 Pass, 10 Rush, 4 TD |
| RB | James Conner | Ari | DNP | 15.35 | 214.90 | Did Not Play |
| RB | Darrel Williams | KC | 24.20 | 10.39 | 166.30 | 88 Rush, 19 Receiving, 3 Rec, 2 TD |
| WR | Marquise Brown | Bal | 3.30 | 11.84 | 177.60 | 28 Receiving, 3 Rec, 1 Fumb |
| WR | Ja'Marr Chase | Cin | 50.10 | 16.34 | 261.50 | 266 Receiving, 11 Rec, 3 TD |
| WR | Stefon Diggs | Buf | 7.50 | 13.45 | 215.20 | - 2 Rush, 52 Receiving, 5 Rec |
| TE | Mark Andrews | Bal | 11.90 | 14.69 | 235.10 | 89 Receiving, 6 Rec |
| HB | Odell Beckham | LAR | 12.40 | 8.02 | 104.30 | 39 Receiving, 5 Rec, 1 TD |
| PK | Matt Gay | LAR | 2.00 | 9.44 | 151.00 | 2 XP |
| DL | Aaron Donald | LAR | 10.00 | 8.81 | 141.00 | 3 Tackles, 2 Assists, 0.5 Sack, 1 FF |
| DL | Cameron Heyward | Pit | 10.00 | 8.69 | 139.00 | 4 Tackles, 1.0 Sack, 2 PD |
| DL | Sam Hubbard | Cin | 5.00 | 6.44 | 103.00 | 2 Tackles, 3 Assists |
| LB | Jordan Hicks | Ari | 1.00 | 9.00 | 144.00 | 1 Tackle |
| LB | C.J. Mosley | NYJ | 13.00 | 11.40 | 171.00 | 7 Tackles, 6 Assists |
| LB | Roquan Smith | Chi | 9.00 | 11.31 | 181.00 | 6 Tackles, 3 Assists |
| CB | Logan Ryan | NYG | 6.00 | 9.00 | 126.00 | 3 Tackles, 2 Assists, 1 PD |
| S | Derwin James | LAC | 6.00 | 10.00 | 140.00 | 4 Tackles, 2 Assists |
| Pos. | 1st Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Tua Tagovailoa | Mia | 0(5.30) | 16.65 | 199.76 | 205 Pass, 1 Rush, 1 Int, 1 Fumb |
| RB | Melvin Gordon | Den | 8.70 | 11.14 | 167.10 | 43 Rush, 29 Receiving, 3 Rec |
| WR | Gabriel Davis | Buf | 0(5.50) | 6.87 | 103.00 | 40 Receiving, 3 Rec |
| TE | Gerald Everett | Sea | 0(5.10) | 6.66 | 93.30 | 36 Receiving, 3 Rec |
| TE | Dalton Schultz | Dal | 0(8.40) | 9.64 | 154.20 | 54 Receiving, 6 Rec |
| PK | Nicholas Folk | NE | 0(8.00) | 9.94 | 159.00 | 1 FG(40-49), 5 XP, 1 Miss(<40) |
| DL | Kenny Clark | GB | 0(1.00) | 4.07 | 61.00 | 1 Tackle |
| LB | Fred Warner | SF | 0(18.00) | 9.67 | 145.00 | 7 Tackles, 8 Assists, 1 FF |
| S | Jayron Kearse | Dal | 0(7.00) | 8.13 | 130.00 | 5 Tackles, 1 Assist, 1 PD |
| Pos. | 2nd Backup | Proteam | TW | PPG | Total | Breakdown |
| QB | Jimmy Garoppolo | SF | DNP | 18.27 | 255.76 | Did Not Play |
| RB | Mike Davis | Atl | 0(12.20) | 7.31 | 116.90 | 42 Rush, 15 Receiving, 1 Rec, 1 TD |
| WR | Mecole Hardman | KC | 0(5.80) | 6.13 | 98.10 | 53 Receiving, 1 Rec |
| RB | David Johnson | Hou | DNP | 5.10 | 61.20 | Did Not Play |
| Offense = 162.94 Defense = 60 Total = 222.94 | ||||||
| Pos. | Bench | Proteam | TW | PPG | Total | Breakdown |
| QB | Kirk Cousins | Min | DNP | 22.70 | 340.44 | Did Not Play |
| WR | Cole Beasley | Buf | 5.20 | 7.55 | 113.20 | 22 Receiving, 2 Rec, 1 2-Pt |
| WR | Robert Woods | LAR | DNP | 12.78 | 115.00 | Did Not Play |
| Pos. | Injured List | Proteam | TW | PPG | Total | Breakdown |
| RB | Christian McCaffrey | Car | DNP | 15.57 | 109.00 | Did Not Play |