| Round | Overall | Player |
|---|---|---|
| 1 | 6th | WR Calvin Johnson Det |
| 2 | 19th | RB Giovani Bernard Cin |
| 3 | 30th | WR Vincent Jackson TB |
| 4 | 43rd | RB Ryan Mathews SD |
| 5 | 54th | WR DeSean Jackson Was |
| 6 | 67th | RB Trent Richardson Ind |
| 7 | 78th | QB Tony Romo Dal |
| 8 | 91st | WR Mike Wallace Mia |
| 9 | 102nd | RB Fred Jackson Buf |
| 10 | 115th | WR Reggie Wayne Ind |
| 11 | 126th | DL Jason Pierre-Paul NYG |
| 12 | 139th | LB Jared Allen Chi |
| 13 | 150th | LB Daryl Smith Bal |
| 14 | 163rd | LB Paul Worrilow Atl |
| 15 | 174th | TE Antonio Gates SD |
| 16 | 187th | PK Stephen Gostkowski NE |
| 17 | 198th | S T.J. Ward Den |
| 18 | 211th | QB Alex Smith KC |
| 19 | 222nd | CB Tramon Williams GB |
| 20 | 235th | RB Bobby Rainey TB |
| 21 | 246th | WR Aaron Dobson NE |
| 22 | 259th | LB Thomas Davis Car |
| 23 | 270th | TE Coby Fleener Ind |
| 24 | 283rd | CB Lardarius Webb Bal |
| 25 | 294th | S Ryan Clark Was |
| 26 | 307th | DL Cliff Avril Sea |
| 27 | 318th | DL Dontari Poe KC |
| 28 | 331st | WR Robert Woods Buf |