| Name | Team | Games | PPG | Total Pts. | Pos. | PPG Rank | Total Rank |
| Josh Allen |
|
12 | 26.01 | 312 | QB | 1st | 1st |
| Chris Boswell |
|
12 | 9.08 | 109 | PK | 9th | 6th |
| Marquise Brown |
|
12 | 8.03 | 96 | WR | 50th | 41st |
| Brian Burns |
|
13 | 9.31 | 121 | DL | 3rd | 2nd |
| Tyson Campbell |
|
12 | 8.58 | 103 | CB | 2nd | 2nd |
| Blake Cashman |
|
8 | 10.88 | 87 | LB | 8th | 38th |
| Lavonte David |
|
12 | 8.92 | 107 | LB | 28th | 21st |
| Cameron Dicker |
|
12 | 10.08 | 121 | PK | 6th | 3rd |
| Stefon Diggs |
|
13 | 9.27 | 121 | WR | 39th | 24th |
| Emeka Egbuka |
|
12 | 12.00 | 144 | WR | 13th | 9th |
| Mike Evans |
|
4 | 6.75 | 27 | WR | 59th | 115th |
| Ollie Gordon II |
|
12 | 3.45 | 41 | RB | 72nd | 60th |
| Cedric Gray |
|
12 | 10.67 | 128 | LB | 9th | 5th |
| Derrick Henry |
|
12 | 14.36 | 172 | RB | 12th | 10th |
| Cameron Heyward |
|
12 | 5.50 | 66 | DL | 40th | 26th |
| Jalyx Hunt |
|
12 | 5.08 | 61 | DL | 47th | 33rd |
| Cameron Jordan |
|
12 | 5.17 | 62 | DL | 44th | 31st |
| Kamari Lassiter |
|
12 | 7.17 | 86 | CB | 10th | 6th |
| Trey McBride |
|
12 | 14.99 | 180 | TE | 1st | 1st |
| Keaton Mitchell |
|
8 | 3.80 | 30 | RB | 69th | 67th |
| Kyle Monangai |
|
12 | 8.65 | 104 | RB | 34th | 28th |
| Jayden Reed |
|
1 | 12.00 | 12 | WR | 13th | 149th |
| Khalil Shakir |
|
12 | 8.49 | 102 | WR | 46th | 36th |
| Jamien Sherwood |
|
12 | 9.67 | 116 | LB | 17th | 16th |
| Roquan Smith |
|
10 | 10.20 | 102 | LB | 14th | 27th |
| Tykee Smith |
|
12 | 9.83 | 118 | S | 2nd | 1st |
| Amon-Ra St. Brown |
|
12 | 15.07 | 181 | WR | 7th | 4th |
| Rhamondre Stevenson |
|
10 | 8.08 | 81 | RB | 40th | 39th |
| Geno Stone |
|
12 | 8.83 | 106 | S | 6th | 5th |
| Mitchell Trubisky |
|
3 | 0.75 | 2 | QB | 55th | 55th |
| Jaylen Waddle |
|
12 | 11.04 | 133 | WR | 22nd | 15th |
| Darren Waller |
|
5 | 9.28 | 46 | TE | 11th | 36th |
| Rachaad White |
|
12 | 8.26 | 99 | RB | 36th | 31st |