| Week | Add | Drop |
| Week 1 |
Round 2: S Nick Emmanwori  |
Round 2: WR Amari Cooper  |
| Week 2 |
Round 1: S Jaylinn Hawkins  |
Round 1: S Nick Emmanwori |
| Week 3 |
Round 1: WR Tyquan Thornton  Round 2: TE Adam Trautman  |
Round 1: RB Austin Ekeler  Round 2: TE Cade Otton  |
| Week 4 |
Round 1: TE Cole Kmet  |
Round 1: TE Adam Trautman |
| Week 5 |
Round 1: CB Isaiah Rodgers  Round 2: S DeShon Elliott  |
Round 1: CB Riley Moss Round 2: S Jaylinn Hawkins |
| Week 6 |
Round 1: CB Tyrique Stevenson Round 2: CB Marcus Jones |
Round 1: RB Chris Rodriguez Round 2: CB Isaiah Rodgers |
| Week 7 |
Round 1: LB Tatum Bethune  Round 2: TE Michael Mayer Round 3: WR Darnell Mooney  |
Round 1: LB Terrel Bernard  Round 2: WR Tyquan Thornton Round 3: RB Jaydon Blue  |
| Week 8 |
Round 1: LB SirVocea Dennis Round 2: DL Joey Bosa Round 3: LB Henry To'oTo'o  |
Round 1: WR Christian Kirk Round 2: DL Abdul Carter  Round 3: TE Michael Mayer |
| Week 9 |
Round 1: DL Chase Young  Round 2: S Antoine Winfield Round 3: PK Wil Lutz |
Round 1: S DeShon Elliott Round 2: LB SirVocea Dennis Round 3: WR Marvin Mims |
| Week 10 |
Round 1: TE Darren Waller  Round 2: QB Jacoby Brissett  |
Round 1: TE Evan Engram Round 2: LB Henry To'oTo'o |
| Week 11 |
Round 1: S Quentin Lake  Round 2: DL Jaelan Phillips  Round 3: S Jessie Bates |
Round 1: PK Wil Lutz Round 2: DL Joey Bosa Round 3: S Antoine Winfield |
| Week 12 |
Round 1: LB Cody Simon Round 2: CB Devon Witherspoon Round 3: PK Harrison Butker |
Round 1: S Quentin Lake Round 2: CB Marcus Jones Round 3: LB Tatum Bethune |
| Week 13 |
Round 1: CB Dee Alford Round 3: S Jalen Pitre |
Round 1: CB Tyrique Stevenson Round 3: S Jessie Bates |
| Week 14 |
Round 1: DL Trey Hendrickson  Round 2: WR Christian Kirk |
Round 1: DL Jaelan Phillips Round 2: DL Trey Hendrickson |
| Week 15 |
Round 1: CB D.J. Reed  |
Round 1: CB Dee Alford |
| 1st Team | 2nd Team |
| Pre-Season | |
| Pimpin Ain’t Easy | Tuesday Afternoon |
|
Rookie Round 2, 1st Pick (TE Colston Loveland ) Round 5, 1st Pick (QB Sam Darnold )Round 7, 1st Pick (DL Greg Rousseau ) |
QB
Patrick Mahomes
KC DL Maxx Crosby LV |
| Pre-Season | |
| Pimpin Ain’t Easy | Ohio State Buckeyes |
|
Round 6, 1st Pick (WR Darnell Mooney ) |
DL
T.J. Watt
Pit |
| Pre-Season | |
| Pimpin Ain’t Easy | Tampa Bay Vipers |
|
QB
Trevor Lawrence
Jac |
Round 7, 12th Pick (S Nick Cross  ) |
| Week 5 | |
| Pimpin Ain’t Easy | 49ers |
|
RB
Justice Hill
Bal TE Cole Kmet Chi |
TE
Mark Andrews
Bal RB Tony Pollard Ten |
| Week 9 | |
| Pimpin Ain’t Easy | 49ers |
|
QB
J.J. McCarthy
Min WR Chris Godwin TB WR Brandon Aiyuk SF WR Tory Horton Sea |
WR
Stefon Diggs
NE QB Daniel Jones Ind LB Bobby Okereke NYG LB Jordyn Brooks Mia |
| Week 10 | |
| Pimpin Ain’t Easy | Inside Slant |
|
LB
Fred Warner
SF WR Darnell Mooney Atl |
TE
George Kittle
SF WR D.K. Metcalf Pit |