| Week | Add | Drop |
| Week 2 |
Round 2: QB Daniel Jones  Round 3: CB Jarvis Brownlee Jr.  |
Round 2: LB Payton Wilson  Round 3: CB Cooper DeJean  |
| Week 3 |
Round 1: LB Payton Wilson Round 2: LB Devin Bush  |
Round 1: WR Jaylin Noel  Round 2: DL George Karlaftis  |
| Week 4 |
Round 1: S Kamren Curl  Round 2: CB Tyson Campbell |
Round 1: WR Demario Douglas  Round 2: CB Jarvis Brownlee Jr. |
| Week 5 |
Round 1: WR Adonai Mitchell |
Round 1: S Trevon Moehrig  |
| Week 6 |
Round 1: RB Kimani Vidal  Round 2: RB Braelon Allen |
Round 1: WR Adonai Mitchell Round 2: LB Devin Bush |
| Week 7 |
Round 2: TE AJ Barner  |
Round 2: TE Chig Okonkwo  |
| Week 8 |
Round 1: S Evan Williams  |
Round 1: LB Payton Wilson |
| Week 9 |
Round 1: RB Tank Bigsby Round 3: CB Coby Bryant |
Round 1: S Evan Williams Round 3: RB Tank Bigsby |
| Week 10 |
Round 1: WR Cedric Tillman Round 2: DL Dre'Mont Jones  |
Round 1: TE AJ Barner Round 2: DL DeForest Buckner |
| Week 11 |
Round 2: TE Darren Waller  |
Round 2: WR Cedric Tillman |
| Week 12 |
Round 1: LB Isaiah McDuffie |
Round 1: DL Dre'Mont Jones |
| Week 13 |
Round 1: WR Jahan Dotson |
Round 1: DL Trey Hendrickson  |
| Week 14 |
Round 1: DL Dallas Turner  Round 3: CB Upton Stout  |
Round 1: WR Jahan Dotson Round 3: CB Coby Bryant |
| Week 15 |
Round 1: S Jalen Pitre |
Round 1: QB Daniel Jones |
| 1st Team | 2nd Team |
| Pre-Season | |
| Ann Arbor Wolverines | Boise St Broncos |
|
TE
Travis Kelce
KC |
Round 4, 5th Pick (LB T.J. Edwards  ) |
| Pre-Season | |
| Ann Arbor Wolverines | Boise St Broncos |
|
QB
Baker Mayfield
TB |
Round 3, 5th Pick (PK Brandon Aubrey  ) |
| Pre-Season | |
| Ann Arbor Wolverines | Boise St Broncos |
|
Round 5, 12th Pick (WR Cedric Tillman ) |
LB
Zaire Franklin
Ind |
| Pre-Season | |
| Ann Arbor Wolverines | Kansas St Wildcats |
|
WR
Jakobi Meyers
Jac |
Round 3, 6th Pick (LB Edgerrin Cooper ) |
| Pre-Season | |
| Ann Arbor Wolverines | Canton Bulldogs |
|
QB
Josh Allen
Buf WR D.K. Metcalf Pit Rookie Round 1, 12th Pick (WR Dont'e Thornton Jr.  ) |
QB
Jayden Daniels
Was Rookie Round 1, 3rd Pick (RB TreVeyon Henderson )Round 4, 3rd Pick (DL DeForest Buckner ) |
| Week 9 | |
| Ann Arbor Wolverines | Akron Pros |
|
WR
Davante Adams
LAR |
|
| Week 11 | |
| Ann Arbor Wolverines | Basket Case |
|
RB
Braelon Allen
NYJ |
LB
Tatum Bethune
SF DL Montez Sweat Chi |
| Week 11 | |
| Ann Arbor Wolverines | Basket Case |
|
QB
Cameron Ward
Ten |
QB
Matthew Stafford
LAR WR Jauan Jennings SF |