| Position | Starters | Team | Games | Opponents |
| C | Carson Kelly | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Jonathan Aranda | TB | 6 | KC(3) @NYA(3) |
| 2B | Matt McLain | Cin | 8 | StL(5) Was(3) |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| 3B | Noelvi Marte | Cin | 8 | StL(5) Was(3) |
| OF | Luis Robert Jr. | ChA | 6 | Mil(3) Hou(3) |
| OF | Riley Greene | Det | 7 | @Hou(3) @LAA(4) |
| OF (2B) | Tim Tawa | Ari | 6 | @NYN(3) @Phi(3) |
| DH (OF) | Lars Nootbaar | StL | 8 | @Cin(5) NYN(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Jonah Heim | Tex | 7 | Oak(4) Sea(3) |
| 1B | Rhys Hoskins | Mil | 6 | @ChA(3) ChN(3) |
| 2B | Luis Garcia | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| SS | Geraldo Perdomo | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Caleb Durbin | Mil | 6 | @ChA(3) ChN(3) |
| OF (C) | Hunter Goodman | Col | 7 | Atl(3) @SF(4) |
| DH (1B) | Christian Walker | Hou | 6 | Det(3) @ChA(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Spencer Steer | Cin | 8 | StL(5) Was(3) |
| DH (OF) | Victor Scott | StL | 8 | @Cin(5) NYN(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Michael Conforto | LAD | 6 | Mia(3) @Atl(3) |
| Position | Bench | Team | Games | Opponents |
| 3B | Alex Freeland | LAD | 6 | Mia(3) @Atl(3) |
| OF | Colby Thomas | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Emmanuel Rodriguez | Min | 7 | @Cle(4) @Bos(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Cole Ragans | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday April 24th |
| 2nd SP | Brady Singer | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| 3rd SP | Taj Bradley | TB | 6 | KC(3) @NYA(3) | This Sunday at NYA (Will Warren) |
| 4th SP | Jackson Jobe | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Wednesday April 30th |
| 5th SP | Matthew Liberatore | StL | 8 | @Cin(5) NYN(3) | Last Pitched Thursday May 1st |
| 6th SP | Roki Sasaki | LAD | 6 | Mia(3) @Atl(3) | This Saturday at Atl (Spencer Schwellenbach) |
| 7th SP | Chase Dollander | Col | 7 | Atl(3) @SF(4) | Last Pitched Wednesday April 30th |
| 1st RP | Tanner Scott | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Friday May 2nd |
| 2nd RP | Ryan Walker | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday April 26th |
| Position | Injured List | Team | Games | Opponents |
| 1B | Christian Encarnacion-Strand | Cin | 8 | StL(5) Was(3) |
| SP | George Kirby | Sea | 5 | LAA(2) @Tex(3) |
| 3B | Royce Lewis | Min | 7 | @Cle(4) @Bos(3) |