| Position | Starters | Team | Opponents |
| C | Carson Kelly | ChN | SF(3) @NYN(3) |
| 1B | Jonathan Aranda | TB | Phi(3) Mil(3) |
| 2B | Matt McLain | Cin | @Atl(4) @Hou(3) |
| SS | Corey Seager | Tex | @Bos(3) @Det(3) |
| 3B | Noelvi Marte | Cin | @Atl(4) @Hou(3) |
| OF | Riley Greene | Det | @Col(3) Tex(3) |
| OF | Luis Robert Jr. | ChA | @KC(4) Mia(3) |
| OF (2B) | Tim Tawa | Ari | NYN(3) LAD(4) |
| DH | Lars Nootbaar | StL | Pit(3) @Was(3) |
| Position | 1st Backup | Team | Opponents |
| C | Jonah Heim | Tex | @Bos(3) @Det(3) |
| 1B | Rhys Hoskins | Mil | Hou(3) @TB(3) |
| 2B | Luis Garcia | Was | Cle(3) StL(3) |
| SS | Geraldo Perdomo | Ari | NYN(3) LAD(4) |
| 3B | Caleb Durbin | Mil | Hou(3) @TB(3) |
| OF (C) | Hunter Goodman | Col | Det(3) SD(3) |
| DH | Christian Walker | Hou | @Mil(3) Cin(3) |
| Position | 2nd Backup | Team | Opponents |
| OF (1B) | Spencer Steer | Cin | @Atl(4) @Hou(3) |
| DH | Victor Scott | StL | Pit(3) @Was(3) |
| Position | Bench | Team | Opponents |
| 3B | Alex Freeland | LAD | @Mia(3) @Ari(4) |
| OF | Emmanuel Rodriguez | Min | Bal(3) SF(3) |
| OF | Colby Thomas | Oak | Sea(3) NYA(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Opponents | Next Scheduled Start(s) |
| 1st SP | Cole Ragans | KC | ChA(4) Bos(3) | This Monday vs ChA (Shane Smith) |
| 2nd SP | Brady Singer | Cin | @Atl(4) @Hou(3) | This Monday at Atl (AJ Smith-Shawver) |
| 3rd SP | Taj Bradley | TB | Phi(3) Mil(3) | Last Pitched Tuesday April 29th |
| 4th SP | Jackson Jobe | Det | @Col(3) Tex(3) | This Tuesday at Col (Chase Dollander) |
| 5th SP | Matthew Liberatore | StL | Pit(3) @Was(3) | This Wednesday vs Pit (Mitch Keller) |
| 6th SP | Roki Sasaki | LAD | @Mia(3) @Ari(4) | This Thursday at Ari (Brandon Pfaadt) |
| 7th SP | Chase Dollander | Col | Det(3) SD(3) | This Tuesday vs Det (Jackson Jobe) |
| 8th SP | Eury Perez | Mia | LAD(3) @ChA(3) | Has Not Played Yet |
| 1st RP | Tanner Scott | LAD | @Mia(3) @Ari(4) | Last Pitched Friday May 2nd |
| 2nd RP | Ryan Walker | SF | @ChN(3) @Min(3) | Last Pitched Saturday April 26th |
| Position | Injured List | Team | Opponents |
| 1B | Christian Encarnacion-Strand | Cin | @Atl(4) @Hou(3) |
| 3B | Royce Lewis | Min | Bal(3) SF(3) |
| SP | George Kirby | Sea | @Oak(3) Tor(3) |