| Position | Starters | Team | Games | Opponents |
| C | Logan O'Hoppe | LAA | 6 | @Sea(2) Det(4) |
| 1B | Michael Busch | ChN | 6 | @Pit(3) @Mil(3) |
| 2B | Jose Altuve | Hou | 6 | Det(3) @ChA(3) |
| SS | Francisco Lindor | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 3B | Mark Vientos | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | JJ Bleday | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Aaron Judge | NYA | 6 | @Bal(3) TB(3) |
| OF | James Wood | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| DH (3B) | Jorge Polanco | Sea | 5 | LAA(2) @Tex(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Dillon Dingler | Det | 7 | @Hou(3) @LAA(4) |
| 1B | Ryan Mountcastle | Bal | 6 | NYA(3) KC(3) |
| 2B | Tyler Fitzgerald | SF | 6 | @SD(2) Col(4) |
| SS | Geraldo Perdomo | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Ben Williamson | Sea | 5 | LAA(2) @Tex(3) |
| OF | George Springer | Tor | 6 | Bos(3) Cle(3) |
| DH (OF) | Kameron Misner | TB | 6 | KC(3) @NYA(3) |
| Position | Bench | Team | Games | Opponents |
| C | Ethan Salas | SD | 5 | SF(2) @Pit(3) |
| SS | Colson Montgomery | ChA | 6 | Mil(3) Hou(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Logan Webb | SF | 6 | @SD(2) Col(4) | This Sunday vs Col (Germán Márquez) |
| 2nd SP | Andrew Heaney | Pit | 6 | ChN(3) SD(3) | This Sunday vs SD (Stephen Kolek) |
| 3rd SP | Sonny Gray | StL | 9 | @Cin(5) NYN(4) | Last Pitched Friday May 2nd |
| 4th SP | Andre Pallante | StL | 9 | @Cin(5) NYN(4) | This Sunday vs NYN (Tylor Megill) |
| 5th SP | JP Sears | Oak | 7 | @Tex(4) @Mia(3) | This Sunday at Mia (Edward Cabrera) |
| 6th SP | Hunter Dobbins | Bos | 6 | @Tor(3) Min(3) | Last Pitched Saturday May 3rd |
| 7th SP | Jake Irvin | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Wednesday April 30th |
| 8th SP | Seth Lugo | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday May 1st |
| 9th SP | Davis Martin | ChA | 6 | Mil(3) Hou(3) | Last Pitched Saturday May 3rd |
| 10th SP | Michael McGreevy | StL | 9 | @Cin(5) NYN(4) | Has Not Played Yet |
| 11th SP | Andrew Painter | Phi | 6 | Was(3) Ari(3) | Has Not Played Yet |
| 1st RP | Camilo Doval | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| 2nd RP | Logan Evans | Sea | 5 | LAA(2) @Tex(3) | This Sunday at Tex (Jacob deGrom) |
| Position | Injured List | Team | Games | Opponents |
| SP | Gerrit Cole | NYA | 6 | @Bal(3) TB(3) |
| SP | George Kirby | Sea | 5 | LAA(2) @Tex(3) |