| Position | Starters | Team | Games | Opponents |
| C | Sean Murphy | Atl | 6 | @Col(3) LAD(3) |
| 1B | Bryce Harper | Phi | 6 | Was(3) Ari(3) |
| 2B | Gleyber Torres | Det | 7 | @Hou(3) @LAA(4) |
| SS | Elly De La Cruz | Cin | 8 | StL(5) Was(3) |
| 3B | Jose Ramirez | Cle | 7 | Min(4) @Tor(3) |
| OF | Jarren Duran | Bos | 6 | @Tor(3) Min(3) |
| OF | Kyle Tucker | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Jackson Chourio | Mil | 6 | @ChA(3) ChN(3) |
| DH (OF,1B) | Pavin Smith | Ari | 6 | @NYN(3) @Phi(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Carson Kelly | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Ryan O'Hearn | Bal | 6 | NYA(3) KC(3) |
| 2B | Brandon Lowe | TB | 6 | KC(3) @NYA(3) |
| SS | Masyn Winn | StL | 9 | @Cin(5) NYN(4) |
| 3B | Cam Smith | Hou | 6 | Det(3) @ChA(3) |
| OF | Jasson Dominguez | NYA | 6 | @Bal(3) TB(3) |
| DH (2B,OF) | Gavin Lux | Cin | 8 | StL(5) Was(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| C | Francisco Álvarez | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Jorge Soler | LAA | 6 | @Sea(2) Det(4) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF (C) | Hunter Goodman | Col | 7 | Atl(3) @SF(4) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Spencer Schwellenbach | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| 2nd SP | Dustin May | LAD | 6 | Mia(3) @Atl(3) | This Sunday at Atl (Bryce Elder) |
| 3rd SP | Casey Mize | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Thursday May 1st |
| 4th SP | Hayden Wesneski | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday April 25th |
| 5th SP | Tanner Bibee | Cle | 7 | Min(4) @Tor(3) | This Sunday at Tor (Bowden Francis) |
| 6th SP | Corbin Burnes | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| 7th SP | Sandy Alcantara | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Tuesday April 29th |
| 1st RP | Jeff Hoffman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 2nd RP | Kyle Finnegan | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Thursday May 1st |
| 3rd RP | Emilio Pagan | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 4th RP | Justin Martinez | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Wednesday April 30th |
| 5th RP | Cade Smith | Cle | 7 | Min(4) @Tor(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| OF | Jackson Merrill | SD | 5 | SF(2) @Pit(3) |
| SS | Corey Seager | Tex | 7 | Oak(4) Sea(3) |
| SP | Spencer Strider | Atl | 6 | @Col(3) LAD(3) |