| Position | Starters | Team | Games | Opponents |
| C | Agustin Ramirez | Mia | 6 | @LAD(3) Oak(3) |
| 1B | Tyler Soderstrom | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Marcus Semien | Tex | 7 | Oak(4) Sea(3) |
| SS | Willy Adames | SF | 6 | @SD(2) Col(4) |
| 3B | Alex Bregman | Bos | 6 | @Tor(3) Min(3) |
| OF | Heliot Ramos | SF | 6 | @SD(2) Col(4) |
| OF | Yordan Alvarez | Hou | 6 | Det(3) @ChA(3) |
| OF | Christian Yelich | Mil | 6 | @ChA(3) ChN(3) |
| DH (1B) | Freddie Freeman | LAD | 6 | Mia(3) @Atl(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Austin Wells | NYA | 6 | @Bal(3) TB(3) |
| 1B | Matt Mervis | Mia | 6 | @LAD(3) Oak(3) |
| 2B | Bryson Stott | Phi | 6 | Was(3) Ari(3) |
| SS | Jordan Lawlar | Ari | 6 | @NYN(3) @Phi(3) |
| 3B | Ke'Bryan Hayes | Pit | 6 | ChN(3) SD(3) |
| OF | Roman Anthony | Bos | 6 | @Tor(3) Min(3) |
| DH (1B) | Triston Casas | Bos | 6 | @Tor(3) Min(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| C | J.T. Realmuto | Phi | 6 | Was(3) Ari(3) |
| 1B | Bryce Eldridge | SF | 6 | @SD(2) Col(4) |
| 2B | Otto Lopez | Mia | 6 | @LAD(3) Oak(3) |
| OF | Alex Verdugo | Atl | 6 | @Col(3) LAD(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Matt Wallner | Min | 7 | @Cle(4) @Bos(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Cole Ragans | KC | 6 | @TB(3) @Bal(3) | Last Pitched Thursday April 24th |
| 2nd SP | Bubba Chandler | Pit | 6 | ChN(3) SD(3) | Has Not Played Yet |
| 3rd SP | Cristopher Sanchez | Phi | 6 | Was(3) Ari(3) | Last Pitched Wednesday April 30th |
| 4th SP | Taj Bradley | TB | 6 | KC(3) @NYA(3) | This Sunday at NYA (Will Warren) |
| 5th SP | Matt Boyd | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Wednesday April 30th |
| 6th SP | Michael Wacha | KC | 6 | @TB(3) @Bal(3) | Last Pitched Friday May 2nd |
| 7th SP | Max Meyer | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Saturday May 3rd |
| 8th SP | José Soriano | LAA | 6 | @Sea(2) Det(4) | Last Pitched Friday May 2nd |
| 1st RP | Felix Bautista | Bal | 6 | NYA(3) KC(3) | Last Pitched Friday May 2nd |
| 2nd RP | José Alvarado | Phi | 6 | Was(3) Ari(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| 2B | Luke Keaschall | Min | 7 | @Cle(4) @Bos(3) |
| SP | Shane McClanahan | TB | 6 | KC(3) @NYA(3) |
| SP | Grayson Rodriguez | Bal | 6 | NYA(3) KC(3) |