| Position | Starters | Team | Games | Opponents |
| C | Yainer Diaz | Hou | 6 | Det(3) @ChA(3) |
| 1B | Paul Goldschmidt | NYA | 6 | @Bal(3) TB(3) |
| 2B | Matt McLain | Cin | 8 | StL(5) Was(3) |
| SS | J.P. Crawford | Sea | 5 | LAA(2) @Tex(3) |
| 3B (2B,OF) | Zach McKinstry | Det | 7 | @Hou(3) @LAA(4) |
| OF | Wilyer Abreu | Bos | 6 | @Tor(3) Min(3) |
| OF | Mike Trout | LAA | 6 | @Sea(2) Det(4) |
| OF | Corbin Carroll | Ari | 6 | @NYN(3) @Phi(3) |
| DH (OF) | Michael Harris II | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Keibert Ruiz | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 1B | Michael Toglia | Col | 7 | Atl(3) @SF(4) |
| 2B | Luisangel Acuna | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| SS | Xander Bogaerts | SD | 5 | SF(2) @Pit(3) |
| 3B | Junior Caminero | TB | 6 | KC(3) @NYA(3) |
| OF | Randy Arozarena | Sea | 5 | LAA(2) @Tex(3) |
| DH (OF) | Chandler Simpson | TB | 6 | KC(3) @NYA(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 3B | Matt Shaw | ChN | 6 | @Pit(3) @Mil(3) |
| Position | Bench | Team | Games | Opponents |
| 1B | Deyvison De Los Santos | Mia | 6 | @LAD(3) Oak(3) |
| 1B | Jac Caglianone | KC | 6 | @TB(3) @Bal(3) |
| 2B | Christian Moore | LAA | 6 | @Sea(2) Det(4) |
| SS | Carson Williams | TB | 6 | KC(3) @NYA(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Robbie Ray | SF | 6 | @SD(2) Col(4) | Last Pitched Friday May 2nd |
| 2nd SP | Luis Castillo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Saturday May 3rd |
| 3rd SP | Chris Sale | Atl | 6 | @Col(3) LAD(3) | Last Pitched Wednesday April 30th |
| 4th SP | Freddy Peralta | Mil | 6 | @ChA(3) ChN(3) | This Sunday vs ChN (Shota Imanaga) |
| 5th SP | Joe Ryan | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Friday May 2nd |
| 6th SP | Brayan Bello | Bos | 6 | @Tor(3) Min(3) | Last Pitched Friday May 2nd |
| 7th SP | Kris Bubic | KC | 6 | @TB(3) @Bal(3) | Last Pitched Saturday May 3rd |
| 8th SP | Bailey Ober | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Saturday May 3rd |
| 1st RP | Andres Munoz | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Raisel Iglesias | Atl | 6 | @Col(3) LAD(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| 3B | Royce Lewis | Min | 7 | @Cle(4) @Bos(3) |
| 1B | Luis Arraez | SD | 5 | SF(2) @Pit(3) |
| SS | Ezequiel Tovar | Col | 7 | Atl(3) @SF(4) |