| Position | Starters | Team | Games | Opponents |
| C | Adley Rutschman | Bal | 6 | NYA(3) KC(3) |
| 1B | Vladimir Guerrero Jr. | Tor | 6 | Bos(3) Cle(3) |
| 2B | Andrés Gimenez | Tor | 6 | Bos(3) Cle(3) |
| SS | Gunnar Henderson | Bal | 6 | NYA(3) KC(3) |
| 3B | Matt Chapman | SF | 6 | @SD(2) Col(4) |
| OF | Juan Soto | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Lawrence Butler | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Oneil Cruz | Pit | 6 | ChN(3) SD(3) |
| DH (OF) | Riley Greene | Det | 7 | @Hou(3) @LAA(4) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Gabriel Moreno | Ari | 6 | @NYN(3) @Phi(3) |
| 1B | Nathaniel Lowe | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| 2B (SS) | Gabriel Arias | Cle | 7 | Min(4) @Tor(3) |
| SS | Dansby Swanson | ChN | 6 | @Pit(3) @Mil(3) |
| 3B | Ryan McMahon | Col | 7 | Atl(3) @SF(4) |
| OF | Sal Frelick | Mil | 6 | @ChA(3) ChN(3) |
| DH (1B) | Eric Wagaman | Mia | 6 | @LAD(3) Oak(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Trent Grisham | NYA | 6 | @Bal(3) TB(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Hunter Greene | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 2nd SP | Bryan Woo | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Friday May 2nd |
| 3rd SP | Jack Flaherty | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Saturday May 3rd |
| 4th SP | Randy Vasquez | SD | 5 | SF(2) @Pit(3) | Last Pitched Saturday May 3rd |
| 5th SP | Ryan Pepiot | TB | 6 | KC(3) @NYA(3) | Last Pitched Friday May 2nd |
| 6th SP | Griffin Canning | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Monday April 28th |
| 7th SP | Carlos Rodon | NYA | 6 | @Bal(3) TB(3) | Last Pitched Tuesday April 29th |
| 8th SP | MacKenzie Gore | Was | 7 | NYN(1) @Phi(3) @Cin(3) | This Sunday at Cin (Nick Martinez) |
| 9th SP | Reese Olson | Det | 7 | @Hou(3) @LAA(4) | This Sunday at LAA (Jack Kochanowicz) |
| 10th SP | Yusei Kikuchi | LAA | 6 | @Sea(2) Det(4) | Last Pitched Thursday May 1st |
| 11th SP | Eduardo Rodriguez | Ari | 6 | @NYN(3) @Phi(3) | This Sunday at Phi (Ranger Suarez) |
| 12th SP | Tanner Houck | Bos | 6 | @Tor(3) Min(3) | Last Pitched Thursday May 1st |
| 1st RP | Ryan Pressly | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Thursday May 1st |
| 2nd RP | Abner Uribe | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| SP | Brandon Woodruff | Mil | 6 | @ChA(3) ChN(3) |
| OF | Josh Lowe | TB | 6 | KC(3) @NYA(3) |
| 2B | Ketel Marte | Ari | 6 | @NYN(3) @Phi(3) |