| Position | Starters | Team | Games | Opponents |
| C | Jonah Heim | Tex | 7 | Oak(4) Sea(3) |
| 1B | Matt Olson | Atl | 6 | @Col(3) LAD(3) |
| 2B | Kristian Campbell | Bos | 6 | @Tor(3) Min(3) |
| SS | Bo Bichette | Tor | 6 | Bos(3) Cle(3) |
| 3B (SS,OF) | Jose Caballero | TB | 6 | KC(3) @NYA(3) |
| OF | Jung Hoo Lee | SF | 6 | @SD(2) Col(4) |
| OF | Byron Buxton | Min | 7 | @Cle(4) @Bos(3) |
| OF | Cody Bellinger | NYA | 6 | @Bal(3) TB(3) |
| DH | Marcell Ozuna | Atl | 6 | @Col(3) LAD(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Alejandro Kirk | Tor | 6 | Bos(3) Cle(3) |
| 1B | Rhys Hoskins | Mil | 6 | @ChA(3) ChN(3) |
| 2B | Ozzie Albies | Atl | 6 | @Col(3) LAD(3) |
| SS | Carlos Correa | Min | 7 | @Cle(4) @Bos(3) |
| 3B | Matt Vierling | Det | 7 | @Hou(3) @LAA(4) |
| OF | Nick Castellanos | Phi | 6 | Was(3) Ari(3) |
| DH (OF) | Alec Burleson | StL | 9 | @Cin(5) NYN(4) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Christian Encarnacion-Strand | Cin | 8 | StL(5) Was(3) |
| 3B | Max Muncy | LAD | 6 | Mia(3) @Atl(3) |
| OF | Evan Carter | Tex | 7 | Oak(4) Sea(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Paul Skenes | Pit | 6 | ChN(3) SD(3) | Last Pitched Thursday May 1st |
| 2nd SP | Framber Valdez | Hou | 6 | Det(3) @ChA(3) | Last Pitched Friday May 2nd |
| 3rd SP | Max Fried | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 4th SP | Zac Gallen | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Thursday May 1st |
| 5th SP | Kevin Gausman | Tor | 6 | Bos(3) Cle(3) | Last Pitched Saturday May 3rd |
| 6th SP | Shane Baz | TB | 6 | KC(3) @NYA(3) | Last Pitched Thursday May 1st |
| 7th SP | Brandon Pfaadt | Ari | 6 | @NYN(3) @Phi(3) | Last Pitched Saturday May 3rd |
| 8th SP | Spencer Arrighetti | Hou | 6 | Det(3) @ChA(3) | Last Pitched Saturday April 5th |
| 9th SP | Mitch Keller | Pit | 6 | ChN(3) SD(3) | Last Pitched Friday May 2nd |
| 1st RP | Robert Suarez | SD | 5 | SF(2) @Pit(3) | Last Pitched Saturday May 3rd |
| 2nd RP | Ryan Walker | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| 3rd RP | Kenley Jansen | LAA | 6 | @Sea(2) Det(4) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| SP | Jared Jones | Pit | 6 | ChN(3) SD(3) |
| C | Tyler Stephenson | Cin | 8 | StL(5) Was(3) |
| 2B | Thairo Estrada | Col | 7 | Atl(3) @SF(4) |