| Position | Starters | Team | Games | Opponents |
| C | Salvador Perez | KC | 6 | @TB(3) @Bal(3) |
| 1B | Christian Walker | Hou | 6 | Det(3) @ChA(3) |
| 2B | Brendan Donovan | StL | 9 | @Cin(5) NYN(4) |
| SS | Trea Turner | Phi | 6 | Was(3) Ari(3) |
| 3B | Manny Machado | SD | 5 | SF(2) @Pit(3) |
| OF | Lars Nootbaar | StL | 9 | @Cin(5) NYN(4) |
| OF | Brandon Nimmo | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| OF | Taylor Ward | LAA | 6 | @Sea(2) Det(4) |
| DH (SS) | Mookie Betts | LAD | 6 | Mia(3) @Atl(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Miguel Amaya | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Nolan Schanuel | LAA | 6 | @Sea(2) Det(4) |
| 2B | Jake Cronenworth | SD | 5 | SF(2) @Pit(3) |
| SS | Orlando Arcia | Atl | 6 | @Col(3) LAD(3) |
| 3B | Ernie Clement | Tor | 6 | Bos(3) Cle(3) |
| OF | Andrew Benintendi | ChA | 6 | Mil(3) Hou(3) |
| DH (OF,1B) | Spencer Steer | Cin | 8 | StL(5) Was(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| DH (OF) | Victor Robles | Sea | 5 | LAA(2) @Tex(3) |
| Position | 3rd Backup | Team | Games | Opponents |
| OF | Tyler O'Neill | Bal | 6 | NYA(3) KC(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Bryce Miller | Sea | 5 | LAA(2) @Tex(3) | Last Pitched Tuesday April 29th |
| 2nd SP | Nick Martinez | Cin | 8 | StL(5) Was(3) | This Sunday vs Was (MacKenzie Gore) |
| 3rd SP | Brady Singer | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| 4th SP | Pablo Lopez | Min | 7 | @Cle(4) @Bos(3) | Last Pitched Wednesday April 30th |
| 5th SP | Tyler Anderson | LAA | 6 | @Sea(2) Det(4) | Last Pitched Wednesday April 30th |
| 6th SP | Mitchell Parker | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Friday May 2nd |
| 7th SP | Jameson Taillon | ChN | 6 | @Pit(3) @Mil(3) | Last Pitched Saturday May 3rd |
| 8th SP | Matthew Liberatore | StL | 9 | @Cin(5) NYN(4) | Last Pitched Thursday May 1st |
| 9th SP | Jose Quintana | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Saturday May 3rd |
| 10th SP | Jordan Hicks | SF | 6 | @SD(2) Col(4) | Last Pitched Saturday May 3rd |
| 11th SP | Kutter Crawford | Bos | 6 | @Tor(3) Min(3) | Has Not Played Yet |
| 12th SP | Shane Bieber | Cle | 7 | Min(4) @Tor(3) | Has Not Played Yet |
| 13th SP | Gavin Stone | LAD | 6 | Mia(3) @Atl(3) | Has Not Played Yet |
| Position | Injured List | Team | Games | Opponents |
| SP | Aaron Civale | Mil | 6 | @ChA(3) ChN(3) |
| SP | Ranger Suarez | Phi | 6 | Was(3) Ari(3) |
| DH | Ronald Acuna Jr. | Atl | 6 | @Col(3) LAD(3) |