| Position | Starters | Team | Games | Opponents |
| C | Tyler Heineman | Tor | 6 | Bos(3) Cle(3) |
| 1B | Spencer Torkelson | Det | 7 | @Hou(3) @LAA(4) |
| 2B | Brice Turang | Mil | 6 | @ChA(3) ChN(3) |
| SS | Xavier Edwards | Mia | 6 | @LAD(3) Oak(3) |
| 3B | Nolan Arenado | StL | 9 | @Cin(5) NYN(4) |
| OF | Teoscar Hernández | LAD | 6 | Mia(3) @Atl(3) |
| OF | Cedric Mullins II | Bal | 6 | NYA(3) KC(3) |
| OF | Brenton Doyle | Col | 7 | Atl(3) @SF(4) |
| DH (OF) | Steven Kwan | Cle | 7 | Min(4) @Tor(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | William Contreras | Mil | 6 | @ChA(3) ChN(3) |
| 1B | Jonathan Aranda | TB | 6 | KC(3) @NYA(3) |
| 2B | Wilmer Flores | SF | 6 | @SD(2) Col(4) |
| SS | Edmundo Sosa | Phi | 6 | Was(3) Ari(3) |
| 3B | Josh Smith | Tex | 7 | Oak(4) Sea(3) |
| OF (2B) | Tim Tawa | Ari | 6 | @NYN(3) @Phi(3) |
| DH (3B,2B,OF) | Dylan Moore | Sea | 5 | LAA(2) @Tex(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Vinnie Pasquantino | KC | 6 | @TB(3) @Bal(3) |
| 2B (1B) | Romy Gonzalez | Bos | 6 | @Tor(3) Min(3) |
| 3B | Alec Bohm | Phi | 6 | Was(3) Ari(3) |
| OF | Anthony Santander | Tor | 6 | Bos(3) Cle(3) |
| Pitching Staff Alignment |
| 8 Starts, 1 Reliever |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Chris Bassitt | Tor | 6 | Bos(3) Cle(3) | Last Pitched Friday May 2nd |
| 2nd SP | Tarik Skubal | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Friday May 2nd |
| 3rd SP | Tylor Megill | NYN | 8 | @Was(1) Ari(3) @StL(4) | This Sunday at StL (Andre Pallante) |
| 4th SP | Zack Wheeler | Phi | 6 | Was(3) Ari(3) | Last Pitched Tuesday April 29th |
| 5th SP | Michael King | SD | 5 | SF(2) @Pit(3) | Last Pitched Wednesday April 30th |
| 6th SP | Kodai Senga | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Thursday May 1st |
| 7th SP | Pat Corbin | Tex | 7 | Oak(4) Sea(3) | Last Pitched Saturday May 3rd |
| 8th SP | Bowden Francis | Tor | 6 | Bos(3) Cle(3) | This Sunday vs Cle (Tanner Bibee) |
| 9th SP | Landen Roupp | SF | 6 | @SD(2) Col(4) | Last Pitched Wednesday April 30th |
| 10th SP | Erick Fedde | StL | 9 | @Cin(5) NYN(4) | This Sunday vs NYN (Blade Tidwell) |
| 1st RP | Mason Miller | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Saturday May 3rd |
| Position | Injured List | Team | Games | Opponents |
| SP | Reynaldo Lopez | Atl | 6 | @Col(3) LAD(3) |