| Position | Starters | Team | Games | Opponents |
| C | Sean Murphy | Atl | 6 | @Col(3) LAD(3) |
| 1B | Pete Alonso | NYN | 8 | @Was(1) Ari(3) @StL(4) |
| 2B | Marcus Semien | Tex | 7 | Oak(4) Sea(3) |
| SS | Dansby Swanson | ChN | 6 | @Pit(3) @Mil(3) |
| 3B | Manny Machado | SD | 5 | SF(2) @Pit(3) |
| OF | Pete Crow-Armstrong | ChN | 6 | @Pit(3) @Mil(3) |
| OF | Julio Rodriguez | Sea | 5 | LAA(2) @Tex(3) |
| OF | Brenton Doyle | Col | 7 | Atl(3) @SF(4) |
| DH | Shohei Ohtani | LAD | 6 | Mia(3) @Atl(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Yainer Diaz | Hou | 6 | Det(3) @ChA(3) |
| 1B | Jonathan Aranda | TB | 6 | KC(3) @NYA(3) |
| 2B | Otto Lopez | Mia | 6 | @LAD(3) Oak(3) |
| SS | Xavier Edwards | Mia | 6 | @LAD(3) Oak(3) |
| 3B | Ben Williamson | Sea | 5 | LAA(2) @Tex(3) |
| OF | Alex Verdugo | Atl | 6 | @Col(3) LAD(3) |
| DH (OF) | Adolis Garcia | Tex | 7 | Oak(4) Sea(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| 1B | Bryce Eldridge | SF | 6 | @SD(2) Col(4) |
| 2B | Travis Bazzana | Cle | 7 | Min(4) @Tor(3) |
| OF | Kameron Misner | TB | 6 | KC(3) @NYA(3) |
| DH (2B) | Hyeseong Kim | LAD | 6 | Mia(3) @Atl(3) |
| Pitching Staff Alignment |
| 7 Starts, 2 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Shota Imanaga | ChN | 6 | @Pit(3) @Mil(3) | This Sunday at Mil (Freddy Peralta) |
| 2nd SP | Jacob deGrom | Tex | 7 | Oak(4) Sea(3) | This Sunday vs Sea (Logan Evans) |
| 3rd SP | Freddy Peralta | Mil | 6 | @ChA(3) ChN(3) | This Sunday vs ChN (Shota Imanaga) |
| 4th SP | MacKenzie Gore | Was | 7 | NYN(1) @Phi(3) @Cin(3) | This Sunday at Cin (Nick Martinez) |
| 5th SP | Shane Smith | ChA | 6 | Mil(3) Hou(3) | Last Pitched Wednesday April 30th |
| 6th SP | Gavin Williams | Cle | 7 | Min(4) @Tor(3) | Last Pitched Saturday May 3rd |
| 7th SP | Sandy Alcantara | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Tuesday April 29th |
| 8th SP | Jackson Jobe | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Wednesday April 30th |
| 1st RP | Aroldis Chapman | Bos | 6 | @Tor(3) Min(3) | Last Pitched Wednesday April 30th |
| 2nd RP | Pete Fairbanks | TB | 6 | KC(3) @NYA(3) | Last Pitched Saturday May 3rd |
| 3rd RP | Trevor Megill | Mil | 6 | @ChA(3) ChN(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| SP | Eury Perez | Mia | 6 | @LAD(3) Oak(3) |
| OF | Matt Wallner | Min | 7 | @Cle(4) @Bos(3) |
| SP | Shane McClanahan | TB | 6 | KC(3) @NYA(3) |