| Position | Starters | Team | Games | Opponents |
| C | Cal Raleigh | Sea | 5 | LAA(2) @Tex(3) |
| 1B | Michael Busch | ChN | 6 | @Pit(3) @Mil(3) |
| 2B | Jazz Chisholm Jr. | NYA | 6 | @Bal(3) TB(3) |
| SS | Zach Neto | LAA | 6 | @Sea(2) Det(4) |
| 3B | Junior Caminero | TB | 6 | KC(3) @NYA(3) |
| OF | James Wood | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| OF | Fernando Tatis Jr. | SD | 5 | SF(2) @Pit(3) |
| OF | Wyatt Langford | Tex | 7 | Oak(4) Sea(3) |
| DH (SS) | Trevor Story | Bos | 6 | @Tor(3) Min(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Joey Bart | Pit | 6 | ChN(3) SD(3) |
| 1B | Nick Kurtz | Oak | 7 | @Tex(4) @Mia(3) |
| 2B | Tyler Fitzgerald | SF | 6 | @SD(2) Col(4) |
| SS (2B) | Gabriel Arias | Cle | 7 | Min(4) @Tor(3) |
| 3B | Isaac Paredes | Hou | 6 | Det(3) @ChA(3) |
| OF | Dylan Crews | Was | 7 | NYN(1) @Phi(3) @Cin(3) |
| DH (3B) | Royce Lewis | Min | 7 | @Cle(4) @Bos(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| SS | Jordan Lawlar | Ari | 6 | @NYN(3) @Phi(3) |
| OF | Sal Frelick | Mil | 6 | @ChA(3) ChN(3) |
| DH (3B,OF) | Cam Smith | Hou | 6 | Det(3) @ChA(3) |
| Position | Bench | Team | Games | Opponents |
| SS | Marcelo Mayer | Bos | 6 | @Tor(3) Min(3) |
| Pitching Staff Alignment |
| 5 Starts, 3 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Mitchell Parker | Was | 7 | NYN(1) @Phi(3) @Cin(3) | Last Pitched Friday May 2nd |
| 2nd SP | Tyler Mahle | Tex | 7 | Oak(4) Sea(3) | Last Pitched Thursday May 1st |
| 3rd SP | Casey Mize | Det | 7 | @Hou(3) @LAA(4) | Last Pitched Thursday May 1st |
| 4th SP | Luis Severino | Oak | 7 | @Tex(4) @Mia(3) | Last Pitched Wednesday April 30th |
| 5th SP | Drew Rasmussen | TB | 6 | KC(3) @NYA(3) | Last Pitched Wednesday April 30th |
| 6th SP | Roki Sasaki | LAD | 6 | Mia(3) @Atl(3) | Last Pitched Saturday May 3rd |
| 7th SP | Griffin Canning | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Monday April 28th |
| 1st RP | Ryan Helsley | StL | 9 | @Cin(5) NYN(4) | Last Pitched Friday May 2nd |
| 2nd RP | Emilio Pagan | Cin | 8 | StL(5) Was(3) | Last Pitched Friday May 2nd |
| 3rd RP | Luke Weaver | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| 4th RP | Devin Williams | NYA | 6 | @Bal(3) TB(3) | Last Pitched Friday May 2nd |
| Position | Injured List | Team | Games | Opponents |
| SP | Ranger Suarez | Phi | 6 | Was(3) Ari(3) |