| Position | Starters | Team | Games | Opponents |
| C | Carson Kelly | ChN | 6 | @Pit(3) @Mil(3) |
| 1B | Matt Olson | Atl | 6 | @Col(3) LAD(3) |
| 2B | Luke Keaschall | Min | 7 | @Cle(4) @Bos(3) |
| SS | Bo Bichette | Tor | 6 | Bos(3) Cle(3) |
| 3B | Austin Riley | Atl | 6 | @Col(3) LAD(3) |
| OF | Lawrence Butler | Oak | 7 | @Tex(4) @Mia(3) |
| OF | Oneil Cruz | Pit | 6 | ChN(3) SD(3) |
| OF | Chandler Simpson | TB | 6 | KC(3) @NYA(3) |
| DH (OF) | Wilyer Abreu | Bos | 6 | @Tor(3) Min(3) |
| Position | 1st Backup | Team | Games | Opponents |
| C | Edgar Quero | ChA | 6 | Mil(3) Hou(3) |
| 1B | Eric Wagaman | Mia | 6 | @LAD(3) Oak(3) |
| 2B (3B,OF) | Jonathan India | KC | 6 | @TB(3) @Bal(3) |
| SS | Jacob Wilson | Oak | 7 | @Tex(4) @Mia(3) |
| 3B | Noelvi Marte | Cin | 8 | StL(5) Was(3) |
| OF | Heliot Ramos | SF | 6 | @SD(2) Col(4) |
| DH (OF) | Andrew Benintendi | ChA | 6 | Mil(3) Hou(3) |
| Position | 2nd Backup | Team | Games | Opponents |
| OF | Justyn-Henry Malloy | Det | 7 | @Hou(3) @LAA(4) |
| Position | Bench | Team | Games | Opponents |
| 1B | Jac Caglianone | KC | 6 | @TB(3) @Bal(3) |
| 1B | Christian Encarnacion-Strand | Cin | 8 | StL(5) Was(3) |
| 3B | Matt Shaw | ChN | 6 | @Pit(3) @Mil(3) |
| DH (OF) | Roman Anthony | Bos | 6 | @Tor(3) Min(3) |
| Pitching Staff Alignment |
| 10 Starts, 0 Relievers |
| Position | Pitching Order | Team | Games | Opponents | Next Scheduled Start |
| 1st SP | Garrett Crochet | Bos | 6 | @Tor(3) Min(3) | This Sunday vs Min (Chris Paddack) |
| 2nd SP | Walker Buehler | Bos | 6 | @Tor(3) Min(3) | Last Pitched Saturday April 26th |
| 3rd SP | Kodai Senga | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Thursday May 1st |
| 4th SP | Max Meyer | Mia | 6 | @LAD(3) Oak(3) | Last Pitched Saturday May 3rd |
| 5th SP | Tyler Anderson | LAA | 6 | @Sea(2) Det(4) | Last Pitched Wednesday April 30th |
| 6th SP | Tomoyuki Sugano | Bal | 6 | NYA(3) KC(3) | Last Pitched Saturday May 3rd |
| 7th SP | Justin Verlander | SF | 6 | @SD(2) Col(4) | Last Pitched Thursday May 1st |
| 8th SP | Pat Corbin | Tex | 7 | Oak(4) Sea(3) | Last Pitched Saturday May 3rd |
| 1st RP | Edwin Diaz | NYN | 8 | @Was(1) Ari(3) @StL(4) | Last Pitched Saturday April 26th |
| 2nd RP | Alexis Diaz | Cin | 8 | StL(5) Was(3) | Last Pitched Wednesday April 30th |
| Position | Injured List | Team | Games | Opponents |
| 2B | Zack Gelof | Oak | 7 | @Tex(4) @Mia(3) |
| SP | Spencer Arrighetti | Hou | 6 | Det(3) @ChA(3) |
| C | Tyler Stephenson | Cin | 8 | StL(5) Was(3) |